The paradox of high apolipoprotein A-I levels independently predicting incident type-2 diabetes among Turks

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dc.contributor.authorOnat, Altan
dc.contributor.authorHergenç, Gülay
dc.contributor.authorBulur, Serkan
dc.contributor.authorUğur, Murat
dc.contributor.authorKüçükdurmaz, Zekeriya
dc.contributor.authorCan, Günay
dc.date.accessioned2020-04-30T23:33:59Z
dc.date.available2020-04-30T23:33:59Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000278651800013en_US
dc.descriptionPubMed: 19171400en_US
dc.description.abstractBackground: Predictive value of apolipoprotein (apo) A-I for incident hypertension, metabolic syndrome (MetS), type 2 diabetes (DM) and coronary heart disease (CHD) needs further exploration. Methods: A representative sample of Turkish adults was studied with this purpose prospectively. Sex-specific apoA-I tertiles were examined regarding cardiometabolic risk. Results and conclusions: A total of 1044 men and 1067 women (aged 49 +/- 12 years at baseline) were followed up over 7.4 years. High serum apoA-I levels were significantly associated in multivariable analysis with female sex, aging, alcohol intake, (inversely) cigarette smoking and, in women, with systolic blood pressure. Risk of diabetes was predicted in logistic regression in both genders by top versus bottom apoA-I tertile (RR 1.98; [ 95% CI 1.31; 3.0]), additive to age, body mass index (BMI), C-reactive protein (CRP), HDL-cholesterol and lipid lowering drugs. By adding sex hormone-binding globulin to the model in a subset of the sample, the association between high apoA-I and incident diabetes was attenuated only in women. ApoA-I tertiles tended to be positively associated also with hypertension and CHD only in women but this did not reach significance. High compared with low serum apoA-I levels nearly double the risk for incident diabetes, additively to age, BMI, CRP, HDL-cholesterol among Turks. Systemic inflammation concomitant with prevailing MetS might turn apoA-I into proinflammatory particles. (C) 2008 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2008.12.066en_US
dc.identifier.endpage79en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2008.12.066
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5083
dc.identifier.volume142en_US
dc.identifier.wosWOS:000278651800013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdiponectinen_US
dc.subjectApolipoprotein A-Ien_US
dc.subjectCoronary heart diseaseen_US
dc.subjectDiabetes type-2en_US
dc.subjectSystemic inflammationen_US
dc.subjectMetabolic syndromeen_US
dc.titleThe paradox of high apolipoprotein A-I levels independently predicting incident type-2 diabetes among Turksen_US
dc.typeArticleen_US

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