Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty

Basit Öğe Kaydı
dc.contributor.authorÇetinkaya, Semra
dc.contributor.authorPoyrazoğlu, Şükran
dc.contributor.authorBaş, Firdevs
dc.contributor.authorErcan, Oya
dc.contributor.authorYıldız, Metin
dc.contributor.authorAdal, Erdal
dc.contributor.authorDarendeliler, Feyza
dc.date.accessioned2020-04-30T23:31:40Z
dc.date.available2020-04-30T23:31:40Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionABALI, SAYGIN/0000-0001-6552-2801; Abaci, Ayhan/0000-0002-1812-0321; Buyukinan, Muammer/0000-0002-2937-823X; Mengen, Eda/0000-0003-1597-8418en_US
dc.descriptionWOS: 000423677900009en_US
dc.descriptionPubMed: 29353264en_US
dc.description.abstractBackground: The aim of the study was to assess the response to growth hormone (GH) treatment in very young patients with GH deficiency (GHD) through a national, multi-center study. Possible factors affecting growth response were assessed (especially mini-puberty). Methods: Medical reports of GHD patients in whom treatment was initiated between 0 and 3 years of age were retrospectively evaluated. Results: The cohort numbered 67. The diagnosis age was 12.4 +/- 8.6 months, peak GH stimulation test response (at diagnosis) as 1.0 +/- 1.4 ng/mL. The first and second years length gain was 15.0 +/- 4.3 and 10.4 +/- 3.4 cm. Weight gain had the largest effect on first year growth response; whereas weight gain and GH dose were both important factors affecting second year growth response. In the multiple pituitary hormone deficiency (MPHD) group (n = 50), first year GH response was significantly greater than in the isolated GH deficiency (IGHD) group (n = 17) (p = 0.030). In addition first year growth response of infants starting GH between 0 and 12 months of age (n = 24) was significantly greater than those who started treatment between 12 and 36 months of age (n = 43) (p < 0.001). These differences were not seen in the second year. Delta Length/height standard deviation score (SDS), Delta body weight SDS, length/height SDS, weight SDS in MPHD without hypogonadism for the first year of the GH treatment were found as significantly better than MPHD with hypogonadism. Conclusions: Early onsets of GH treatment, good weight gain in the first year of the treatment and good weight gain-GH dose in the second year of the treatment are the factors that have the greatest effect on length gain in early onset GHD. The presence of the sex steroid hormones during minipubertal period influence growth pattern positively under GH treatment (closer to the normal percentage according to age and gender).en_US
dc.description.sponsorshipTurkish Pediatric Endocrinology and Diabetes Society [022014]en_US
dc.description.sponsorshipThis work was supported by the Turkish Pediatric Endocrinology and Diabetes Society (Grant Number: 022014).en_US
dc.identifier.doi10.1515/jpem-2017-0123en_US
dc.identifier.endpage184en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2017-0123
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4399
dc.identifier.volume31en_US
dc.identifier.wosWOS:000423677900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal Of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgrowth hormone deficiencyen_US
dc.subjectgrowth hormone treatmenten_US
dc.subjectgrowth responseen_US
dc.subjectinfancyen_US
dc.subjectmini-pubertyen_US
dc.titleResponse to growth hormone treatment in very young patients with growth hormone deficiencies and mini-pubertyen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4399.pdf
Boyut:
192.99 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu