Does determination of drug level in intoxicated patients offer an advantage in diagnosis, treatment, and reducing complications?

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dc.authoridibrahim, abdullah/0000-0002-4111-1335
dc.authoridTAYFUR, Ismail/0000-0002-4852-7915
dc.contributor.authorTayfur, Ismail
dc.contributor.authorSenel, Ahmet
dc.contributor.authorColak, Sahin
dc.contributor.authorIbrahim, Abdullah
dc.contributor.authorAfacan, Mustafa Ahmet
dc.contributor.authorSaritas, Ayhan
dc.date.accessioned2021-12-01T18:48:56Z
dc.date.available2021-12-01T18:48:56Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: To investigate the effect of determining the drug type and level on emergency management in patients presenting with intoxication, and to identify the factors behind associated mortality. Methods: The retrospective, observational, cross-sectional and single -centre study was conducted at a large tertiary care teaching hospital in Istanbul, Turkey, between September and November 2016 using the hospital's toxicology registry. Data was extracted for patients who had presented to the emergency department from January 1, 2011, to February 28, 2013, and were found to have toxic doses of single active ingredients in the plasma. The patients were evaluated in terms of age, gender, demographic characteristics, time from ingestion to presentation, reason for drug ingestion, type of drug ingested, time elapsed before the emergency service was called, treatment given, drug level, hospitalisation and mortality. Data was analysed using SPSS 11.5. Results: Of the 224 patients, 145(64.8%) were women. The overall mean age was 30.8 +/- 15.4 years. Drug ingestion was more common in women aged 18-30 years (p<0.0001). Besides, 215(96%) patients had ingested drugs with the intent to commit suicide. The minimum education level of 163(72.8%) patients was high school. The most frequently ingested drug was paracetamol 90(40.2%). Overall mortality was 4(1.8%) and all of them were brought to the emergency department after a delay of more than five hours (p<0.0001). Conclusion: Drug type and quantity were found to be of great importance in taking timely decisions while attending to patients with intoxication in an emergency setting. Delay in presentation was associated with mortality.en_US
dc.identifier.doi10.5455/JPMA.7631
dc.identifier.endpage829en_US
dc.identifier.issn0030-9982
dc.identifier.issue5en_US
dc.identifier.pmid32400735en_US
dc.identifier.scopus2-s2.0-85084626195en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage825en_US
dc.identifier.urihttps://doi.org/10.5455/JPMA.7631
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10635
dc.identifier.volume70en_US
dc.identifier.wosWOS:000546394200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPakistan Medical Assocen_US
dc.relation.ispartofJournal Of The Pakistan Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntoxicationen_US
dc.subjectPlasma toxic dosesen_US
dc.subjectEergencyen_US
dc.subjectDrug levelsen_US
dc.subjectPoisoningsen_US
dc.titleDoes determination of drug level in intoxicated patients offer an advantage in diagnosis, treatment, and reducing complications?en_US
dc.typeArticleen_US

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