COMPARISON OF HCV RNA AND HCV CORE ANTIGEN IN GENOTYPE 1 CHRONIC HEPATITIS C PATIENTS

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dc.contributor.authorKarabay, Oğuz
dc.contributor.authorÖğütlü, Aziz
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorÖzdemir, Fatma
dc.contributor.authorKarabay, Meltem
dc.contributor.authorGözdaş, Hasan Tahsin
dc.date.accessioned2020-04-30T22:41:19Z
dc.date.available2020-04-30T22:41:19Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523; Karabay, Oguz/0000-0003-0502-432Xen_US
dc.descriptionWOS: 000364114800009en_US
dc.description.abstractBackground: Anti-HCV test is currently used in the diagnosis of hepatitis C, while hepatitis C virus ribonucleic acid (HCV RNA) is used in the determination of viral load. Recently developed hepatitis C virus core antigen (HCV Ag) test is also used in the diagnosis of hepatitis C. The aim of this study was to compare HCV Ag and quantitative HCV RNA in terms of sensitivity and specificity as well as pharmacoeconomic footprint. Patients and methods: Sixty patients with positive anti-HCV were enrolled to this study. Quantitative HCV RNA was studied by ready commercial kits (Qiagen, lower limit of <12 IU/ml). HCV Ag test was studied with microparticule chemiluminiscent immunoassay method using ready commercial kits (Architect HCV Ag, Abbott). Conclusions: HCV Ag and HCV RNA levels were measured in the sera of chronic hepatitis C patients. Quite high correlation was found between the two tests (r = 0.83). According to our results, HCV Ag test may be an alternative to quantitative reverse transcription polymerase chain reaction (PCR) test. Thus, use of HCV Ag in place of HCV RNA will be more cost-effective for countries with limited sources.en_US
dc.identifier.endpage1028en_US
dc.identifier.issn0393-6384
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1025en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3165
dc.identifier.volume30en_US
dc.identifier.wosWOS:000364114800009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHCV Agen_US
dc.subjectHCV RNAen_US
dc.subjecthepatitis Cen_US
dc.subjectdiagnosisen_US
dc.subjectfollow-upen_US
dc.subjectcost-effectivenessen_US
dc.titleCOMPARISON OF HCV RNA AND HCV CORE ANTIGEN IN GENOTYPE 1 CHRONIC HEPATITIS C PATIENTSen_US
dc.typeArticleen_US

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