Predictors of major adverse cardiovascular events; results of population based MELEN study with prospective follow-up

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dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorAslantaş, Yusuf
dc.contributor.authorEkinözü, İsmail
dc.contributor.authorTibilli, Hakan
dc.contributor.authorKayapınar, Osman
dc.date.accessioned2020-04-30T23:21:24Z
dc.date.available2020-04-30T23:21:24Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000354535200018en_US
dc.descriptionPubMed: 25967720en_US
dc.description.abstractOBJECTIVE: In healthy persons, cardiovascular risk is the result of multiple interacting risk associates including demographic, clinical, genetic and environmental factors. Several non-invasive tools such as echocardiography, ultrasonography and electrocardiography as well as new biochemical markers were shown to be applicable to predict cardiovascular events. However, implementation of all of these tools has not been tested before. The aim of the study was to evaluate the independent predictors of major adverse cardiovascular events in a prospective population based study, with the use of bioempedance analysis, echocardiography, ultrasonography and ECG. PATIENTS AND METHODS: The baseline measurements were conducted on 2230 participants (1427 women, 803 men with a mean age of 49 +/- 15). The follow-up was done 36 months after the baseline admission via telephone call. Major adverse event was defined as mortality or myocardial infarction or stroke. RESULTS: Follow-up data was possible in 1495 participants (65%). During the follow-up of 36 months (4485 patient years), 42 major adverse events occurred (0.03%). Among them, 16 were death (1 stroke, 2 cancer, 13 cardiac related), 12 were stroke and 14 were myocardial infarction. Age, body mass index and atrial fibrillation were independent predictors of major adverse events; AF being the most powerful (Odds ratio 10.46; 95% confidence interval [1.73-63.14]; p = 0.010). CONCLUSIONS: Age, lower body mass index and atrial fibrillation were independent predictors of major cardiovascular events in our cohort.en_US
dc.description.sponsorshipDuzce University Bureau of Scientific InvestigationsDuzce University [2009.04.03.034]en_US
dc.description.sponsorshipThis study was funded in full by Duzce University Bureau of Scientific Investigations, grant number 2009.04.03.034.en_US
dc.identifier.endpage1451en_US
dc.identifier.issn1128-3602
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1446en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4187
dc.identifier.volume19en_US
dc.identifier.wosWOS:000354535200018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiovascular eventen_US
dc.subjectPredictoren_US
dc.subjectAtrial fibrillationen_US
dc.titlePredictors of major adverse cardiovascular events; results of population based MELEN study with prospective follow-upen_US
dc.typeArticleen_US

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