Decreasing myocardial estrogen receptors and antioxidant activity may be responsible for increasing ischemia- and reperfusion-induced ventricular arrhythmia in older female rats

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dc.authoridBozdogan, Omer/0000-0001-5073-0691
dc.contributor.authorBozdogan, Omer
dc.contributor.authorBozcaarmutlu, Azra
dc.contributor.authorKaya, Salih Tunc
dc.contributor.authorSapmaz, Canan
dc.contributor.authorOzarslan, Talat Ogulcan
dc.contributor.authorEksioglu, Didem
dc.contributor.authorYasar, Selcuk
dc.date.accessioned2021-12-01T18:49:37Z
dc.date.available2021-12-01T18:49:37Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractAims: This study aimed to investigate the relationship between ischemia- and reperfusion-induced arrhythmia and blood serum estrogen levels, myocardial estrogen receptor levels, antioxidant enzyme activities, and the effects of the estrogen receptor blocker, fulvestrant (ICI 182 780). Main methods: A total of 102 female Sprague-Dawley rats of different ages (2-3, 6-7, 14-15, and 20-21 months) were used in this study. Myocardial ischemia was produced by ligation of the descending branch of the left anterior descending coronary artery, and reperfusion was produced by releasing this artery. An electrocardiogram (ECG) and blood pressure were recorded for 6 min of ischemia and 6 min of reperfusion. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), estrogen receptor alpha (ER alpha), and estrogen receptor beta (ER beta) in myocardial tissue and 17 beta-estradiol (E2) in blood serum were measured via enzyme-linked immunosorbent assay (ELISA). The results were compared using a Mann-Whitney U test, one-way analysis of variance (ANOVA), and a student's t-test. Key findings: It is not the changes in serum estrogen levels but the decreasing myocardial estrogen receptors and antioxidant activities that could be responsible for the occurrence of more severe arrhythmia in response to reperfusion in older female rats. Significance: The death rate due to a heart attack in younger men is higher than in women. However, it equalizes after the menopausal stage in women. In this study, the reason for the increasing sudden post-menopausal death rate in women was investigated experimentally.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Projects Coordination Unit Turkey [BAP-2016.03.01.998]en_US
dc.description.sponsorshipThis work was supported by Bolu Abant Izzet Baysal University Scientific Research Projects Coordination Unit Turkey [grant number BAP-2016.03.01.998].en_US
dc.identifier.doi10.1016/j.lfs.2021.119190
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.scopus2-s2.0-85100632588en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2021.119190
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10752
dc.identifier.volume271en_US
dc.identifier.wosWOS:000626600400027en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgingen_US
dc.subjectMyocardialen_US
dc.subjectArrhythmiaen_US
dc.subjectAntioxidanten_US
dc.subjectRaten_US
dc.titleDecreasing myocardial estrogen receptors and antioxidant activity may be responsible for increasing ischemia- and reperfusion-induced ventricular arrhythmia in older female ratsen_US
dc.typeArticleen_US

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