Serum transforming growth factor-beta levels in patients with vitamin D deficiency

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dc.contributor.authorIşık, Serhat
dc.contributor.authorÖzuğuz, Ufuk
dc.contributor.authorTütüncü, Yasemin Ateş
dc.contributor.authorErden, Gönül
dc.contributor.authorBerker, Dilek
dc.contributor.authorAcar, Kadir
dc.contributor.authorGüler, Serdar
dc.date.accessioned2020-04-30T23:31:53Z
dc.date.available2020-04-30T23:31:53Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000298148800028en_US
dc.descriptionPubMed: 22153539en_US
dc.description.abstractBackground: Transforming growth factor-beta 1 (TGF-beta 1) contributes to tissue repair by promoting tissue fibrosis, and elevations have been reported in patients with bone marrow fibrosis. The aim of this study was to evaluate the relationship between TGF-beta 1 levels and vitamin D deficiency. Methods: All patients presenting to the outpatient Endocrinology and Metabolic Diseases clinic between June and September of 2008 were approached, and consenting patients who were deemed suitable candidates were enrolled. Hematological parameters were measured, along with serum levels of total and ionized calcium, phosphorus, parathyroid hormone, iron, folic acid vitamin B12 levels, 25 OH vitamin D3 (25OHD(3)) and TGF-beta 1. Results: A total of 132 patients were included in the study. Patients were divided into 4 groups based on levels of 25OHD(3) [group 1 (< 5 ng/ml), 20 patients; group 2 (5-15 ng/ml), 38 patients; group 3 (16-30 ng/ml); and group 4 (> 30 ng/ml), 28 patients]. TGF-beta 1 levels were higher in patients in group 1 compared to the other groups. Transforming growth factor-beta levels correlated negatively with vitamin D3 and positively with leukocyte count, platelet count, of MCV and MCH. Multiple regression analyses revealed TGF-beta 1 levels to be associated with 25OHD(3) as well as with platelet count. Conclusions: Results of this study are suggestive of the presence of a significant relationship between TGF-beta and vitamin D deficiency. Increased TGF-beta 1 and platelet count may be an early indicator of bone marrow fibrosis in patients with vitamin D deficiency. Crown Copyright (C) 2011 Published by Elsevier B. V. on behalf of European Federation of Internal Medicine. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejim.2011.09.017en_US
dc.identifier.endpage97en_US
dc.identifier.issn0953-6205
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejim.2011.09.017
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4520
dc.identifier.volume23en_US
dc.identifier.wosWOS:000298148800028en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Internal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin Den_US
dc.subjectTransforming growth factor-beta 1en_US
dc.subjectBone marrow fibrosisen_US
dc.titleSerum transforming growth factor-beta levels in patients with vitamin D deficiencyen_US
dc.typeArticleen_US

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