The effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liver

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dc.authoridKAYA, Salih Tunc/0000-0002-4133-407X
dc.authoridOzarslan, Talat Ogulcan/0000-0002-2635-7011
dc.authorwosidKilinc, Leyla K/I-8856-2017
dc.authorwosidBozdogan, Omer/AAG-5151-2021
dc.contributor.authorBozcaarmutlu, Azra
dc.contributor.authorSapmaz, Canan
dc.contributor.authorBozdogan, Omer
dc.contributor.authorKukner, Aysel
dc.contributor.authorKilinc, Leyla
dc.contributor.authorKaya, Salih Tunc
dc.contributor.authorEksioglu, Didem
dc.date.accessioned2021-12-01T18:50:18Z
dc.date.available2021-12-01T18:50:18Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractIt is possible to use plant-derived antioxidant molecules in the form of dietary supplements. However, dietary supplement-drug interaction pattern has not been well defined for most of these products. The aim of this study was to determine the effects of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rats. Streptozotocin was administered to create experimental diabetes. Resveratrol (5 mg/kg) (R), glibenclamide (5 mg/kg) (G), and berberine (10 mg/kg) (B) were administered individually or in combinations in DMSO by intraperitoneal administration route to the diabetic rats. DMSO was also given to non-diabetic control (C) and diabetic control (D) groups. Livers of rats were taken under anesthesia at the end of the treatment period (12 days). Ethoxyresorufin O-deethylase (EROD), pentoxyresorufin O-depentylase (PROD), aniline 4-hydroxylase (A4H), erythromycin N-demethylase (ERND), glutathione S-transferase (GST), catalase (CAT), and glutathione reductase (GR) activities were measured in microsomes and cytosols. In addition, histomorphological studies were also performed in the liver tissues. EROD activity of D+R was significantly higher than C and D+R+B. PROD activity of D+R was significantly higher than C, D, D+R+G, D+R+B, and D+R+B+ G. PROD activity of D+B was significantly higher than C and D+R+B. ERND activity of D+R was significantly higher than D+R+G and D+R+B. GST activity of D+R was significantly higher than D+R+G. CAT activity of D+B was significantly lower than C. It is clear that co-administration of resveratrol, berberine, and glibenclamide modifies some of the important xenobiotic metabolizing enzyme activities. Resveratrol and berberine have the potential to cause dietary supplement-drug interaction.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University [BAP-2015.03.03.898]en_US
dc.description.sponsorshipThis research was supported by Bolu Abant Izzet Baysal University [Project No.: BAP-2015.03.03.898].en_US
dc.identifier.doi10.1080/01480545.2020.1802475
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.pmid32762264en_US
dc.identifier.scopus2-s2.0-85089190247en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1802475
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10857
dc.identifier.wosWOS:000556467400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytochrome P450en_US
dc.subjectdiabetesen_US
dc.subjectberberineen_US
dc.subjectglibenclamideen_US
dc.subjectresveratrolen_US
dc.subjectxenobiotic metabolizing enzymeen_US
dc.subjectIn-Vitroen_US
dc.subjectOxidative Stressen_US
dc.subjectCytochrome-P450 2E1en_US
dc.subjectMahonia-Aquifoliumen_US
dc.subjectAntioxidanten_US
dc.subjectExpressionen_US
dc.subjectCatalaseen_US
dc.subjectExtracten_US
dc.subjectCellsen_US
dc.subjectBiotransformationen_US
dc.titleThe effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liveren_US
dc.typeArticleen_US

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