Synthesis, structural aspects, antimicrobial activity and ion transport investigation of five new [1+1] condensed cycloheterophane peptides
dc.contributor.author | Zaim, Ömer | |
dc.contributor.author | Aghatabay, Naz Mohammed | |
dc.contributor.author | Gürbüz, Mustafa Ulvi | |
dc.contributor.author | Baydar, Çağlar | |
dc.contributor.author | Dülger, Başaran | |
dc.date.accessioned | 2020-04-30T23:32:30Z | |
dc.date.available | 2020-04-30T23:32:30Z | |
dc.date.issued | 2014 | |
dc.department | DÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümü | en_US |
dc.description | Zaim, Omer/0000-0002-3472-5611; Dulger, Basaran/0000-0002-3184-2652; Dulger, Basaran/0000-0002-3184-2652; Gurbuz, Mustafa Ulvi/0000-0002-8684-5746 | en_US |
dc.description | WOS: 000334496700015 | en_US |
dc.description.abstract | Five novel [1+1] condensed cycloheterophane peptides were synthesized via reaction of pyridine-2,6-bis(2-aminothiophenoxymethyl) with several diacid chlorides: glutaryl dichloride, adipoyl dichloride, 2,2'-thiodiacetyl chloride, dithiodiglycoloyl chloride and 3,3'-thiodipropionoyl chloride combinations (L-1-L-5). The compounds were characterized by elemental analyses, mass, FT-IR, H-1, and C-13 NMR spectral data. The antimicrobial activities of the compounds were evaluated using the disk diffusion method in dimethyl sulfoxide as well as the minimal inhibitory concentration dilution method, against several bacteria and yeast cultures. The results were compared with those of commercial antibiotic and antifungal agents. Structure activity relationships were also discussed. Permeability of compound L-5 against Na+ and K+ were also investigated. | en_US |
dc.description.sponsorship | Fatih University Scientific Research CentreFatih University [P50021004_G1452]; Trakya UniversityTrakya University [TUBAP-2010/174] | en_US |
dc.description.sponsorship | We would like to extend our gratitude to the Fatih University Scientific Research Centre ( Project-P50021004_G1452) and the Trakya University (Grant # TUBAP-2010/174) for their financial support. Dr. Ahmet Ceyhan Goren and Gokhan Bilsel (TUBITAK-UME), is acknowledged for the Mass analysis. | en_US |
dc.identifier.doi | 10.1007/s10847-012-0282-x | en_US |
dc.identifier.endpage | 159 | en_US |
dc.identifier.issn | 1388-3127 | |
dc.identifier.issn | 1573-1111 | |
dc.identifier.issue | 01.Apr | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 151 | en_US |
dc.identifier.uri | https://doi.org/10.1007/s10847-012-0282-x | |
dc.identifier.uri | https://hdl.handle.net/20.500.12684/4739 | |
dc.identifier.volume | 78 | en_US |
dc.identifier.wos | WOS:000334496700015 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Journal Of Inclusion Phenomena And Macrocyclic Chemistry | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | Cycloheterophane | en_US |
dc.subject | Diffusion | en_US |
dc.subject | Ion transport | en_US |
dc.subject | Permeability | en_US |
dc.title | Synthesis, structural aspects, antimicrobial activity and ion transport investigation of five new [1+1] condensed cycloheterophane peptides | en_US |
dc.type | Article | en_US |
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