Curcumin and LOXblock-1 ameliorate ischemia-reperfusion induced inflammation and acute kidney injury by suppressing the semaphorin-plexin pathway

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dc.authoridkar, fatih/0000-0001-8356-9806
dc.authorwosidhacioglu, ceyhan/ABB-5317-2020
dc.authorwosidkar, fatih/AAI-4540-2021
dc.authorwosidkar, fatih/AAN-4285-2021
dc.contributor.authorKar, Fatih
dc.contributor.authorHacioglu, Ceyhan
dc.contributor.authorSenturk, Hakan
dc.contributor.authorDonmez, Dilek Burukoglu
dc.contributor.authorKanbak, Gungor
dc.contributor.authorUslu, Sema
dc.date.accessioned2021-12-01T18:48:14Z
dc.date.available2021-12-01T18:48:14Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractAims: Ischemia/reperfusion (I/R) is one of the most important causes of acute kidney injury (AKI), a clinical syndrome with kidney dysfunction and high mortality rates. New diagnostic biomarkers need to be defined to better illuminate the pathophysiology of AKI. For the first time, we aim to investigate the protective effects of Curcumin which is known for its antioxidant and anti-inflammatory properties and 12/15 lipoxygenase inhibitor LOXblock-1 on I/R induced AKI by modulating inflammatory processes, oxidative stress, apoptosis and semaphorin-plexin pathway. Main methods: The rats were divided into five groups, with eight animals per group: Sham, I/R, I/R + DMSO (1%, i.p.), I/R + Curcumin (100 mg/kg, i.p.), I/R + LOXblock-1 (2 mu g/kg, i.p.). Key findings: The renal function biomarkers (BUN, CREA and UA) in serum were significantly increased in the I/R group. The inflammatory (TNF-alpha, IL-6 and MCP-1), apoptotic (CYCS and CASP3) and oxidative stress parameters (MDA, MPO, TAS and TOS) measured by ELISA were significantly increased in the I/R group. In histopathological analysis, it was observed that I/R caused serious damage to kidney tissue. SEMA3A was found to increase both serum level and mRNA expression in I/R group. It was observed that curcumin and LOXblock-1 reduce inflammatory processes, oxidative stress and apoptosis via the semaphorin-plexin pathway by both measurements and histopathological analysis. Curcumin was proved more effective than LOXblock-1 with its antioxidant feature in I/R injury. Significance: The current study reveals the protective effects of Curcumin and LOXblock-1 on acute kidney injury by suppressing SEMA3A as a new biomarker.en_US
dc.description.sponsorshipCommission of Scientific Research Projects of Eskisehir Osmangazi University, Eskisehir, Turkey [2019-2344, 2019-1915]en_US
dc.description.sponsorshipThis study was supported by the Commission of Scientific Research Projects of Eskisehir Osmangazi University, Eskisehir, Turkey with the grant numbers: 2019-2344 and 2019-1915.en_US
dc.identifier.doi10.1016/j.lfs.2020.118016
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid32603817en_US
dc.identifier.scopus2-s2.0-85087120412en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2020.118016
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10487
dc.identifier.volume256en_US
dc.identifier.wosWOS:000560765400009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLife Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAKIen_US
dc.subjectRenal I/Ren_US
dc.subjectSEMA3Aen_US
dc.subjectCurcuminen_US
dc.subjectLOXblock-1en_US
dc.subjectRenal Ischemiareperfusion Injuryen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectLiveren_US
dc.subjectAssayen_US
dc.titleCurcumin and LOXblock-1 ameliorate ischemia-reperfusion induced inflammation and acute kidney injury by suppressing the semaphorin-plexin pathwayen_US
dc.typeArticleen_US

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