Comparative effects of metformin and Cistus laurifolius L. extract in streptozotocin-induced diabetic rat model: oxidative, inflammatory, apoptotic, and histopathological analyzes

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dc.authoridYUCEL, Ersin/0000-0001-8274-7578
dc.authoridHacioglu, Ceyhan/0000-0002-0993-6118
dc.authorwosidKara, Yakup/AAW-8736-2020
dc.authorwosidYUCEL, Ersin/AAM-8450-2020
dc.contributor.authorHacioglu, Ceyhan
dc.contributor.authorKar, Fatih
dc.contributor.authorKara, Yakup
dc.contributor.authorYucel, Ersin
dc.contributor.authorDonmez, Dilek Burukoglu
dc.contributor.authorSenturk, Hakan
dc.contributor.authorKanbak, Gungor
dc.date.accessioned2021-12-01T18:50:42Z
dc.date.available2021-12-01T18:50:42Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractInterest in phytochemical therapy methods in the treatment of diabetes is increasing day by day. Although the antidiabetic and antioxidant effects of Cistus laurifolius L. (CL) have been mentioned, the systemic effects remain unknown. The present study aims at evaluating the antidiabetic effects of the CL aqueous extract via metformin on streptozotocin (STZ)-induced diabetic rats. Forty male Wistar albino rats were divided into five groups of eight animals each: control, diabetic group (55mg/kg STZ), STZ+125mg/kg CL, STZ+250mg/kg CL, and STZ+100mg/kg metformin. The effects of CL and metformin on oxidative, apoptotic, and inflammatory pathways were comparatively investigated. In addition, nuclear factor-kappa B (NF kappa B), tumor necrosis factor-alpha (TNF-alpha), and interleukin (IL)-1 beta expressions analysis were carried out. CL treatment resulted in a significant improvement in blood glucose levels, lipid profile, pancreatic markers, and liver and kidney function tests. A 250mg/kg CL treatment decreased by 67.9%, 31.6%, 66.8%, 28.3%, and 31.4% in the total oxidant capacity, NF kappa B, TNF-alpha, IL-1 beta, caspase3, and cytochrome c levels, respectively, compared to the diabetic group. Additionally, CL treatments showed a dose-dependent reduction in NF kappa B, TNF-alpha, and IL-1 beta expression levels. A 250mg/kg CL treatment exhibited a greater increase (by 9.6%) in total antioxidant capacity than metformin. CL treatment provided histologically more improvement in the brain, heart, pancreas, spleen, liver, kidney, and testicular tissues compared to the metformin group. Our results suggest that the single treatment of CL aqueous extract at the low doses may have stronger short-term anti-diabetic effects than metformin. Therefore, further studies are needed regarding the long-term hypoglycemic effect or treatment of CL aqueous extract.en_US
dc.identifier.doi10.1007/s11356-021-14780-y
dc.identifier.endpage57901en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue41en_US
dc.identifier.pmid34097215en_US
dc.identifier.scopus2-s2.0-85107552275en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage57888en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-021-14780-y
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10914
dc.identifier.volume28en_US
dc.identifier.wosWOS:000658638500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science And Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectCistus laurifolius Len_US
dc.subjectMetforminen_US
dc.subjectOxidative stressen_US
dc.subjectApoptosisen_US
dc.subjectInflammationen_US
dc.subjectHistopathologyen_US
dc.subjectPhenolic-Compoundsen_US
dc.subjectIn-Vivoen_US
dc.subjectFlavonoidsen_US
dc.subjectPathophysiologyen_US
dc.subjectActivationen_US
dc.subjectFractionsen_US
dc.subjectMechanismen_US
dc.subjectGlucoseen_US
dc.subjectLeavesen_US
dc.subjectCellsen_US
dc.titleComparative effects of metformin and Cistus laurifolius L. extract in streptozotocin-induced diabetic rat model: oxidative, inflammatory, apoptotic, and histopathological analyzesen_US
dc.typeArticleen_US

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