Chemical profiling and antimicrobial effect of Anatolian honey bee venom

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dc.authoridAlpay Karaoglu, Sengul/0000-0003-1047-8350
dc.authoridBOZDEVECI, ARIF/0000-0002-0729-9143
dc.contributor.authorSönmez, Emine
dc.contributor.authorKekeçoğlu, Meral
dc.contributor.authorBozdeveci, Arif
dc.contributor.authorKaraoğlu, Şengül Alpay
dc.date.accessioned2023-07-26T11:54:27Z
dc.date.available2023-07-26T11:54:27Z
dc.date.issued2022
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.departmentDÜ, Rektörlük, Arıcılık Araştırma Geliştirme ve Uygulama Merkezien_US
dc.description.abstractDue to increasing antibiotic resistance, there is an urgent need to find new antibiotic alternatives or supporters for the treatment of disease-causing pathogens. For this reason the aim of the study was examine the antimicrobial and antifungal activity of Anatolian (Anadolu) honey bee venom (HBV) against Gram-positive and Gramnegative bacteria and yeast-like fungi. At first step chemical analyses of HBV was performed by HPLC method. According to the results of HPLC analysis, we obtained a good separation of apamine, phospholipase A2 and melittin with the ratio of 1.83%, 20.60% and 57.62% respectively. The antimicrobial and antifungal activity of the Anatolian HBV was tested against 9 Gram (+), 7 Gram (-), 1 acid-alcohol-resistant and 3 yeast fungi. First, the activity of the Anatolian HBV sample against these microorganisms was determined by the agar well diffusion method, then their zones were measured. The microdilution method was used to determine the minimum inhibitory concentration (MIC) for the antimicrobial activity tests. The results of MIC values were varied from 3.06 mu g/mL to 50 mu g/mL for the tested microorganisms. It was found that Mycobacterium smegmatis and Streptococcus pyogenes were the most susceptible bacteria (3.06 mu g/mL), followed by Vibrio sp., Aeromonas sobria, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus (MRSA) and B. subtilis with a MIC concentration of 6.125 mu g/mL. These findings strongly suggest that Anatolian HBV will be developed as a new antibacterial-antifungal drug against Gram-positive, Gram negative and antibiotic-resistant bacteria and yeast like fungi. However, further research is required to evaluate their in vivo efficacy and safe and effective delivery methods for their therapeutic use.en_US
dc.identifier.doi10.1016/j.toxicon.2022.04.006
dc.identifier.endpage6en_US
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.pmid35421436en_US
dc.identifier.scopus2-s2.0-85128210029en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2022.04.006
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12835
dc.identifier.volume213en_US
dc.identifier.wosWOS:000793768800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKekeçoğlu, Meral
dc.institutionauthorSönmez, Emine
dc.institutionauthorAcar, Merve Kambur
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofToxiconen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectAnatolian Honey Bee Venom; Antimicrobial Activity; Hplc; Micen_US
dc.subjectApis-Mellifera Venom; Phospholipase A(2); In-Vitro; Melittin; Acne; Property; Painen_US
dc.titleChemical profiling and antimicrobial effect of Anatolian honey bee venomen_US
dc.typeArticleen_US

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