Protective effect of pristine C60 fullerene nanoparticle in combination with curcumin against hyperglycemia-induced kidney damage in diabetes caused by streptozotocin

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dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authorwosidAslan, Abdullah/C-9523-2016
dc.contributor.authorDemir, Ersin
dc.contributor.authorAslan, Abdullah
dc.date.accessioned2021-12-01T18:47:46Z
dc.date.available2021-12-01T18:47:46Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractThe present study aims to examine the protective effects of C60 fullerene (C60), Curcumin (CUR;Curcuma longa), C60 + CUR combination against oxidative stress, apoptosis, and changes in cellular level in kidney tissue of diabetic rats. Treatment practices were administered separately to groups for 8 weeks following the approval of diabetes induction. It was observed that the treatment groups had increased antioxidant potential, decreased oxidative stress levels, decreased cholesterol, alpha tocopherol, retinol levels along with improved important changes in fatty acid metabolism compared with the diabetic group. C60, CUR, and C60 + CUR were also determined to act in the direction of reducing kidney damage by activating apoptotic pathways. It can be concluded based on these findings that C60, CUR, and especially C60 + CUR combination has beneficial properties in maintaining kidney tissue and function by effectively preventing oxidative stress, apoptotic changes, and changes at the cellular level in kidney tissue under hyperglycemia conditions. Practical applications C60 and CUR have various biological activities which can be indicated as antioxidant, anti-inflammatory, anticancer, neuroprotective, and hepatoprotective. It has been reported that C60 and CUR protect the cells against oxidative injury brought about by reactive oxygen species (ROS). Data acquired from the present study puts forth that C60 and C60 + CUR may be promising agents to prevent damage induced by hyperglycemic conditions in kidney tissue.en_US
dc.description.sponsorshipScientific Research Projects Unit of Duzce UniversityDuzce University [BAP-2017.11.05.657]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Unit of Duzce University (Grant Number: BAP-2017.11.05.657).en_US
dc.identifier.doi10.1111/jfbc.13470
dc.identifier.issn0145-8884
dc.identifier.issn1745-4514
dc.identifier.issue11en_US
dc.identifier.pmid32914898en_US
dc.identifier.scopus2-s2.0-85091359698en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/jfbc.13470
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10368
dc.identifier.volume44en_US
dc.identifier.wosWOS:000567909500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Food Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectC60 fullereneen_US
dc.subjectcurcuminen_US
dc.subjectfat-soluble vitaminsen_US
dc.subjectlipotoxicityen_US
dc.subjectoxidative stressen_US
dc.subjectAttenuates Oxidative Stressen_US
dc.subjectRat Modelen_US
dc.subjectVitamin-Een_US
dc.subjectHigh-Faten_US
dc.subjectExpressionen_US
dc.subjectTissueen_US
dc.subjectLiveren_US
dc.subjectHomeostasisen_US
dc.subjectMetabolismen_US
dc.subjectActivationen_US
dc.titleProtective effect of pristine C60 fullerene nanoparticle in combination with curcumin against hyperglycemia-induced kidney damage in diabetes caused by streptozotocinen_US
dc.typeArticleen_US

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