Platelet function and fibrinolytic activity in patients with bronchial asthma

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dc.contributor.authorTutluoğlu, Bülent
dc.contributor.authorGürel, Çiğdem
dc.contributor.authorÖzdaş, Şule
dc.contributor.authorMüsellim, Benan
dc.contributor.authorErturan, Serdar Eser
dc.contributor.authorAnnakkaya, Ali Nihat
dc.contributor.authorUlutin, Turgut
dc.date.accessioned2020-04-30T23:21:02Z
dc.date.available2020-04-30T23:21:02Z
dc.date.issued2005
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAnnakkaya, Ali Nihat N/0000-0002-7661-8830; Ozdas, Sule Beyhan/0000-0002-4821-4388; Ulutin, Turgut/0000-0002-0406-1746;en_US
dc.descriptionWOS: 000226858400009en_US
dc.descriptionPubMed: 15678276en_US
dc.description.abstractPlatelets have the capacity to release mediators with potent inflammatory or anaphylactic properties. Platelet factor-4 (PF4) and beta-thromboglobulin (BTG) are two of these mediators. On the otter hand, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) are two important mediators of fibrinolysis. Borh mediators are secreted mainly by vascular endothelium. Plasma levels of PF4, BTG, PAI-1, and tPA may show changes in chronic inflammatory diseases such as asthma. This study examined the role of thrombocytes and the function of the endothelium in asthmatic patients during an attack and during a stable phase. Eighteen patients with known allergic asthma who came to our emergency department with an asthma attack and 14 control subjects were included in the study. Blood samples were taken after starting therapy with salbutamol inhalation. Lung function tests were performed after receiving the first emergency therapy for asthma. Plasma levels of PF4, BTG, PA-1, tPA were determined before starting steroid therapy and after receiving 1 week of steroid therapy. Plasma levels of PF4 among patients with an asthma attack were significantly higher than those of controls (150.5 +/- 8.92 IU/mL vs. 92.5 +/- 7.63 IU/mL, p<0.001). A further increase in plasma PF4 levels was detected after steroid therapy (163.5 +/- 9.16 IU/mL). Plasma BTG levels of patients on admission were not statistically different from those in the control group (140.4 +/- 6.34 IU/ml, vs. 152.2 +/- 8.71 IU/mL). An increase was detected after therapy (171.6 +/- 7.27 IU/mL) and post-treatment plasma levels were statistically meaningful versus the controls. Plasma levels of tPA and PAI were statistically higher than those in controls in asthmatic patients on admission (6.01 +/- 2.72 vs. 5.4 +/- 2.3 ng/mL for tPA and 75.2 +/- 27.2 ng/mL vs. 32.7 +/- 14.3 ng/mL for PAI-1). Further increases were detected in two parameters after 1 week of therapy with steroids (tPA levels were 6.85 +/- 2.96 ng/mL and PAI-1 levels were 83.5 +/- 29.6 ng/mL). There seems to be an increased activity of platelets during an asthma attack. Elevated PAI-1 and tPA levels may also indicate the activated endothelium in asthma. Increases of plasma levels of PAI-1 and tPA after steroid therapy need further investigation because elevated PAI-1 levels enhance airway remodeling.en_US
dc.identifier.doi10.1177/107602960501100109en_US
dc.identifier.endpage81en_US
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.1177/107602960501100109
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4125
dc.identifier.volume11en_US
dc.identifier.wosWOS:000226858400009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical And Applied Thrombosis-Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectasthma attacken_US
dc.subjectPF4en_US
dc.subjecttPAen_US
dc.subjectPAI1en_US
dc.subjectBTGen_US
dc.subjectplateleten_US
dc.titlePlatelet function and fibrinolytic activity in patients with bronchial asthmaen_US
dc.typeArticleen_US

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