Omentin serum levels and omentin gene Val109Asp polymorphism in patients with psoriasis

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dc.contributor.authorTuran, Hakan
dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorSoğuktaş, Hatice
dc.contributor.authorYaykaşlı, Emine
dc.contributor.authorAliağaoğlu, Cihangir
dc.contributor.authorErdem, Teoman
dc.contributor.authorBahadır, Anzel
dc.date.accessioned2020-04-30T23:19:51Z
dc.date.available2020-04-30T23:19:51Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionYaykasli, Emine/0000-0001-6471-0106; Yaykasli, Kursat/0000-0001-7550-6370; Kaya, Ertugrul/0000-0003-0081-682Xen_US
dc.descriptionWOS: 000337509800020en_US
dc.descriptionPubMed: 24321036en_US
dc.description.abstractBackground Psoriasis is a chronic inflammatory disease of uncertain pathogenesis. Omentin is a new adipokine with anti-inflammatory properties; however, the relationship between psoriasis and omentin has not been fully established yet. Objectives This study was designed to evaluate the relationship between psoriasis and omentin serum levels and Val109Asp polymorphism in exon 4 of the omentin gene. Methods Forty-nine patients with plaque-type psoriasis and 39 healthy subjects were included in the study. Omentin concentrations were determined by using enzyme-linked immunosorbent assay. Val109Asp polymorphism in exon 4 of the omentin gene was assessed by the polymerase chain reaction-restriction fragment length polymorphism method. Genotypes were determined according to the bands formed in agarose electrophoresis gels. In the statistical analysis, the level of significance was set at P<0.05. Results The serum omentin levels of the patients with psoriasis (354.2 +/- 152.0) were found to be significantly lower than those in the control group (488.7 +/- 190.3) (P=0.001). A moderate level negative correlation was determined between serum omentin level and body mass index and waist circumference. No significant differences were observed between the patient and control groups in terms of the genotype and allele frequency of Val109Asp polymorphism in exon 4 of the omentin gene (0.05). Conclusions Omentin serum levels were determined to be low in patients with psoriasis. No significant difference was found regarding Val109Asp polymorphism of the omentin gene. To the best of our knowledge, our study is the first clinical study to examine the relationship between psoriasis and omentin in terms of serum and genomic levels.en_US
dc.description.sponsorshipDuzce University Scientific Research Projects CommissionDuzce University [2011.04.03.082]en_US
dc.description.sponsorshipThis study was supported by the Duzce University Scientific Research Projects Commission (project no. 2011.04.03.082).en_US
dc.identifier.doi10.1111/ijd.12306en_US
dc.identifier.endpage605en_US
dc.identifier.issn0011-9059
dc.identifier.issn1365-4632
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage601en_US
dc.identifier.urihttps://doi.org/10.1111/ijd.12306
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3867
dc.identifier.volume53en_US
dc.identifier.wosWOS:000337509800020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleOmentin serum levels and omentin gene Val109Asp polymorphism in patients with psoriasisen_US
dc.typeArticleen_US

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