The Effects of Ivabradine on Left Ventricular Synchronization and Tei Index in Patients with Systolic Heart Failure

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dc.contributor.authorErdem, Fatma Hizal
dc.contributor.authorÖztürk, Serkan
dc.contributor.authorÖztürk, Selçuk
dc.contributor.authorErdem, Alim
dc.contributor.authorAyhan, Selim
dc.contributor.authorÖztürk, Mustafa
dc.contributor.authorYazıcı, Mehmet
dc.date.accessioned2020-04-30T23:33:26Z
dc.date.available2020-04-30T23:33:26Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000392042800008en_US
dc.descriptionPubMed: 28115808en_US
dc.description.abstractBackground: The aim of our study was to evaluate in stable outpatients with systolic heart failure (HF) the 3 months effect of ivabradine on LV synchronization and Tei index in stable outpatients with systolic HF. Methods: We evaluated prospectively 40 (30 males, 10 females) patients with HF. All patients were evaluated before and after treatment by transthoracic M mode, two dimensional (2D), pulsed-wave (PW), continuous wave (CW), color flow and tissue Doppler imaging (TDI) and tissue synchronization imaging (TSI). Standard deviation of Ts of the 12 LV segments (Ts-SD-12) is the most widely used parameter of intra-LV asynchrony. Results: Thirty men and 10 women with mean +/- SD age of 64.7 +/- 9.9 years were included in this study. Most of the patients benefitted from some degree of clinical improvement, 12/16 (75.0%) from NYHA III to II and 18/24 (75.0%) from II to I, respectively. Resting heart rate was significantly reduced after ivabradine treatment (84.3 +/- 11.4 vs. 66.5 +/- 11.5 bpm, p <0.001). E/E' and Tei index were significantly changed after ivabradine treatment (17.3 +/- 9.0 vs. 14.8 +/- 7.1, p = 0.02 and 0.86 +/- 0.74 vs. 0.81 +/- 0.69, p = 0.02). Intra-LV synchrony parameters Ts-SD-12 and Ts-12 were significantly reduced after ivabradine (46.8 +/- 13.6 vs. 42.7 +/- 13.1, p = 0.01 and 142.5 +/- 44.0 vs. 128.5 +/- 45.2, p = 0.009). Conclusions: The present study demonstrated that adding ivabradine to the standard therapy reduced HR and significantly improved LV ventricular asynchrony and Tei index in systolic HF patients.en_US
dc.identifier.doi10.6515/ACS20160205Ben_US
dc.identifier.endpage65en_US
dc.identifier.issn1011-6842
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage58en_US
dc.identifier.urihttps://doi.org/10.6515/ACS20160205B
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4969
dc.identifier.volume33en_US
dc.identifier.wosWOS:000392042800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaiwan Soc Cardiologyen_US
dc.relation.ispartofActa Cardiologica Sinicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeart failureen_US
dc.subjectIvabradineen_US
dc.subjectLeft ventricular functionen_US
dc.titleThe Effects of Ivabradine on Left Ventricular Synchronization and Tei Index in Patients with Systolic Heart Failureen_US
dc.typeArticleen_US

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