Comparison of fine needle aspiration biopsy and paraffin embedded tissue sections for measuring AgNOR proteins

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dc.contributor.authorTaşdemir, Şener
dc.contributor.authorEröz, Recep
dc.contributor.authorCücer, Nurhan
dc.contributor.authorOktay, Murat
dc.contributor.authorTürkeli, M.
dc.date.accessioned2020-04-30T22:41:18Z
dc.date.available2020-04-30T22:41:18Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000361304600009en_US
dc.descriptionPubMed: 25843622en_US
dc.description.abstractParaffin embedded tissue sections and fine needle aspiration biopsy (FNAB) are important methods for diagnosis. We compared thyroid tissue obtained by FNAB to paraffin embedded sections to determine whether there were differences in detection of the amounts of argyrophilic nucleolar organizing region (AgNOR) proteins. Twenty-two patients with papillary thyroid carcinoma were included in the study. Slides were prepared with both FNAB tissue and 3 mu m sections of paraffin embedded tissue, and stained for AgNOR. One hundred nuclei per individual were evaluated; total AgNOR number/nucleus (TAn/TNn) and total AgNOR area/nuclear area (TAa/TNa) of individual cells were determined. Mean TAn/TNn and TAa/TNa values were 4.800 +/- 1.118 and 13.382 +/- 2.612, respectively, for FNAB samples; corresponding values were 2.406 +/- 0.649 and 8.49 +/- 0.893, respectively, for paraffin embedded sections. The differences between FNAB materials and paraffin embedded tissue sections were significant for the mean TAn/TNn and TAa/TNa values. Significant differences in the amounts of AgNOR protein detected were found between FNAB and paraffin embedded tissue sections.en_US
dc.identifier.doi10.3109/10520295.2015.1013989en_US
dc.identifier.endpage399en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage395en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2015.1013989
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3161
dc.identifier.volume90en_US
dc.identifier.wosWOS:000361304600009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgNORen_US
dc.subjectFNABen_US
dc.subjectparaffin embedded tissue sectionsen_US
dc.titleComparison of fine needle aspiration biopsy and paraffin embedded tissue sections for measuring AgNOR proteinsen_US
dc.typeArticleen_US

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