Protective Mechanisms of EGCG in Mitigating Oxidative Stress and Liver Toxicity From Cigarette Smoke-Induced Damage

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dc.authoridAKIN, Ali Tugrul/0000-0002-1408-8571;
dc.contributor.authorAgan, Kagan
dc.contributor.authorDemir, Serif
dc.contributor.authorOzmerdivenli, Recep
dc.contributor.authorAgan, Aydan Fulden
dc.contributor.authorAkin, Ali Tugrul
dc.contributor.authorAlpay, Merve
dc.contributor.authorBeyazcicek, Ozge
dc.date.accessioned2025-10-11T20:48:49Z
dc.date.available2025-10-11T20:48:49Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractExposure to cigarette smoke leads to an increase in oxidative stress within the body, resulting in both an elevated oxidant burden and a compromised antioxidant defense system. This imbalance creates a significant risk factor for various diseases by promoting cellular damage, inflammation, and toxicity. The oxidants present in cigarette smoke are considered the primary contributors to these pathological conditions. Supporting the antioxidant system with specific bioactive compounds may help mitigate the toxic effects caused by cigarette smoke. In this study, the effects of EGCG pre-administration on the antioxidant system were evaluated under both acute and chronic exposure conditions to cigarette smoke. Different doses of EGCG were administered to determine its potential role in oxidative stress regulation, and histopathological examinations and antioxidant enzyme levels were assessed. The findings demonstrated that while acute EGCG administration did not significantly improve antioxidant enzyme activity, chronic administration of EGCG at a dose of 50 mg/kg effectively increased antioxidant enzyme production, reduced oxidative stress, and liver injury. In the presence of cigarette smoke, EGCG contributed to the stabilization of oxidative stress markers. However, chronic EGCG administration in the absence of oxidative stressors requires further investigation to assess its impact on other organs. EGCG appears to be a promising candidate for alleviating the adverse effects of external oxidant exposure and mitigating oxidative stress. However, its long-term application and potential side effects in different physiological conditions should be explored further examinations. Although acute EGCG application did not enhance antioxidant enzyme levels, it unexpectedly elevated oxidative stress, emphasizing the need for more comprehensive studies to clarify its mechanisms and optimize its usage. We further identify the principal underlying mechanisms involved in this process.en_US
dc.description.sponsorshipDuzce UEniversitesi [2018.04.01.872]en_US
dc.description.sponsorshipThis work was supported by Duzce UEniversitesi, 2018.04.01.872.en_US
dc.identifier.doi10.1002/fsn3.70472
dc.identifier.issn2048-7177
dc.identifier.issue7en_US
dc.identifier.pmid40625629en_US
dc.identifier.scopus2-s2.0-105009910881en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/fsn3.70472
dc.identifier.urihttps://hdl.handle.net/20.500.12684/22126
dc.identifier.volume13en_US
dc.identifier.wosWOS:001538714100038en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFood Science & Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectcigarette smokeen_US
dc.subjectepigallocatechin gallate (EGCG)en_US
dc.subjectin vivoen_US
dc.subjectliver toxicicityen_US
dc.titleProtective Mechanisms of EGCG in Mitigating Oxidative Stress and Liver Toxicity From Cigarette Smoke-Induced Damageen_US
dc.typeArticleen_US

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