Polymorphisms in MMP-2 and TIMP-2 in Turkish patients with prostate cancer

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dc.contributor.authorYaykaşlı, Kürşat Oğuz
dc.contributor.authorKayıkçı, Muhammet Ali
dc.contributor.authorYamak, Nesibe
dc.contributor.authorSoğuktaş, Hatice
dc.contributor.authorDüzenli, Selma
dc.contributor.authorArslan, Ali Osman
dc.contributor.authorHatipoğlu, Ömer Faruk
dc.date.accessioned2020-04-30T23:21:04Z
dc.date.available2020-04-30T23:21:04Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionHatipoglu, Omer Faruk/0000-0002-1012-001X; Yaykasli, Kursat/0000-0001-7550-6370; Kaya, Ertugrul/0000-0003-0081-682Xen_US
dc.descriptionWOS: 000343068800021en_US
dc.descriptionPubMed: 25539555en_US
dc.description.abstractAim: Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer deaths in the Western male population. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) modulate the remodeling of the extracellular matrix (ECM). The imbalance between MMPs and TIMPs may lead to an emergence of pathological processes such as cancer. In this study, the association between TIMP-2 (-418 G/C) and MMP-2 (-1306 C/T) polymorphisms and prostate cancer in the Turkish population was investigated. Materials and methods: Sixty-one prostate cancer patients and 46 healthy subjects were included in the study. DNA was isolated from 2 mL of peripheral blood taken from subjects, and genotypes were analyzed by the polymerase chain reaction-restriction fragment length polymorphism method. Results: The TIMP-2 418 (GC) genotype was found in 15 cases (32.6%) in the control group and in 9 cases (14.8%) in the patients group, and statistical significance was determined (P = 0.037, OR = 0.346). The MMP-2 1306 (CT) genotype was found 2.17 times more in the patient group than in the control group (P = 0.149, OR = 2.17). Conclusion: Our results show that the TIMP-2 418 (GC) genotype had a putative protective effect against prostate cancer.en_US
dc.description.sponsorshipDuzce University Research FundDuzce University [2012.04.02.107]en_US
dc.description.sponsorshipThis project was supported by the Duzce University Research Fund, Project Number 2012.04.02.107.en_US
dc.identifier.doi10.3906/sag-1305-63en_US
dc.identifier.endpage843en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage839en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1305-63
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4130
dc.identifier.volume44en_US
dc.identifier.wosWOS:000343068800021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMatrix metalloproteinasesen_US
dc.subjectprostate canceren_US
dc.subjectpolymorphismen_US
dc.subjecttissue inhibitors of metalloproteinasesen_US
dc.titlePolymorphisms in MMP-2 and TIMP-2 in Turkish patients with prostate canceren_US
dc.typeArticleen_US

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