Can the Gut Microbiota Serve as a Guide to the Diagnosis and Treatment of Childhood Epilepsy?

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dc.authoridCetiner, Omer Faruk/0000-0002-5132-5353en_US
dc.authoridKayabasi, Eda/0000-0003-0461-335Xen_US
dc.authoridTuray, Sevim/0000-0001-6002-052Xen_US
dc.authorscopusid57208314562en_US
dc.authorscopusid8604063700en_US
dc.authorscopusid58291089900en_US
dc.authorscopusid58290129600en_US
dc.authorscopusid58290314300en_US
dc.authorscopusid58290505100en_US
dc.authorscopusid35571535100en_US
dc.authorwosidCetiner, Omer Faruk/JJD-7100-2023en_US
dc.authorwosidÖZTÜRK, CİHADİYE ELİF/KZU-6169-2024en_US
dc.contributor.authorTuray, Sevim
dc.contributor.authorCangur, Sengul
dc.contributor.authorKahraman, Gozde
dc.contributor.authorKayabasi, Eda
dc.contributor.authorCetiner, Omer Faruk
dc.contributor.authorAydin, Burak
dc.contributor.authorOzturk, Cihadiye Elif
dc.date.accessioned2024-08-23T16:04:35Z
dc.date.available2024-08-23T16:04:35Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractBackground: To investigate the activity of the gut-brain axis in the pathogenesis of childhood epilepsy and to define biomarkers capable of assisting with determining new strategies in that context. Methods: Twenty children with epilepsy of unknown etiology and seven healthy controls in the same age group were included in the study. The groups were compared using a questionnaire. Stool samples were stored in tubes containing DNA/RNA Shield (Zymo Research) with a sterile swab. Sequencing was carried out using the MiSeq System (Illumina). The 16S rRNA sequencing of samples using nextgeneration sequencing involved V4 variable region polymerase chain reaction amplification concluded by 2 x 250-bp paired-end sequencing of amplicons and at least 50,000 reads (>Q30) per sample. DNA sequences were classified at the genus level using the Kraken program. Bioinformatics and statistical analysis were then performed.Results: Individuals' gut microbiota relative abundance values differed between the groups at the genus, order, class, family, and phylum levels. Flavihumibacter, Niabella, Anoxybacillus, Brevundimonas, Devosia, and Delftia were seen only in the control group, whereas Megamonas and Coriobacterium were observed only in the epilepsy group. The linear discriminant analysis effect size method identified 33 taxa as important in differentiating the groups. Conclusions: We think that bacterial varieties (such as Megamonas and Coriobacterium) that differ be-tween the two groups can be employed as useful biomarkers in the diagnosis and follow-up of epileptic patients. We also predict that, in addition to epilepsy treatment protocols, the restoration of eubiotic microbiota may increase the success of treatment.& COPY; 2023 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipDuezce University Scientific Research Projects Unit - Fast Track Project [2021.04.03.1196]en_US
dc.description.sponsorshipThis research was financially supported by the Duezce University Scientific Research Projects Unit under number 2021.04.03.1196 supported by the Fast Track Project.en_US
dc.identifier.doi10.1016/j.pediatrneurol.2023.04.006
dc.identifier.endpage21en_US
dc.identifier.issn0887-8994
dc.identifier.issn1873-5150
dc.identifier.pmid37245274en_US
dc.identifier.scopus2-s2.0-85160321548en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage11en_US
dc.identifier.urihttps://doi.org/10.1016/j.pediatrneurol.2023.04.006
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14280
dc.identifier.volume145en_US
dc.identifier.wosWOS:001012540800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPediatric Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGut microbiotaen_US
dc.subjectChildhood epilepsyen_US
dc.subjectBiomarkeren_US
dc.subjectSeizure controlen_US
dc.subjectDiagnosisen_US
dc.subjectTreatmenten_US
dc.subjectIlae Commissionen_US
dc.subjectSp Nov.en_US
dc.subjectInflammationen_US
dc.subjectDieten_US
dc.titleCan the Gut Microbiota Serve as a Guide to the Diagnosis and Treatment of Childhood Epilepsy?en_US
dc.typeArticleen_US

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