Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes

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dc.contributor.authorTaşdemir, Şener
dc.contributor.authorEröz, Recep
dc.contributor.authorDoğan, Hasan
dc.contributor.authorErdem, Haktan Bağış
dc.contributor.authorŞahin, İbrahim
dc.contributor.authorKara, Murat
dc.contributor.authorTürkez, Hasan
dc.date.accessioned2020-04-30T22:39:51Z
dc.date.available2020-04-30T22:39:51Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionDogan, Hasan/0000-0002-5232-4336en_US
dc.descriptionWOS: 000373932400008en_US
dc.descriptionPubMed: 26866305en_US
dc.description.abstractAims: Nucleolar organizer regions, also known as argyrophilic nucleolar organizer regions, are associated with ribosomal genes. The main function of the nucleolus is the rapid production of ribosomal subunits, a process that must be highly regulated to provide the appropriate levels for cellular proliferation and cell growth. There are no studies in the literature addressing the expression and function of nucleolar component proteins, including nucleophosmin, nucleolin and the upstream binding transcription factor (UBTF), in human follicular hair cells. Methods: Nineteen healthy males who had normal and sufficient hair follicles on the back of the head, but exhibited hair loss on the frontal/vertex portions of the head and 14 healthy males without hair loss were included in the current study. Gene expression levels were measured by relative quantitative real time polymerase chain reaction. Results: In the individuals suffering from alopecia, the total expression levels of nucleolin, nucleophosmin, and UBTF were lower in normal sites than in hair loss sites. Strong expression level correlations were detected between: nucleophosmin and nucleolin; nucleophosmin and UBTF, and nucleolin and UBTF for both groups. Conclusions: There was an association between human hair loss and the expression levels of nucleolin, nucleophosmin, and UBTF genes.en_US
dc.description.sponsorshipAtaturk UniversityAtaturk University [2013/17]en_US
dc.description.sponsorshipThis work was supported by the research grants from Ataturk University (Project No. 2013/17).en_US
dc.identifier.doi10.1089/gtmb.2015.0246en_US
dc.identifier.endpage202en_US
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://doi.org/10.1089/gtmb.2015.0246
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2842
dc.identifier.volume20en_US
dc.identifier.wosWOS:000373932400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofGenetic Testing And Molecular Biomarkersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssociation Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genesen_US
dc.typeArticleen_US

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