The curative effect of cannabinoid 2 receptor agonist on functional failure and disruptive inflammation caused by intestinal ischemia and reperfusion

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dc.authoridARSLAN, SEYFULLAH OKTAY/0000-0001-9328-9373
dc.authoridParlar, Ali/0000-0002-4656-3402
dc.authorwosidArslan, Seyfullah Oktay/AAE-9538-2019
dc.contributor.authorBayram, Sait
dc.contributor.authorParlar, Ali
dc.contributor.authorArslan, Seyfullah Oktay
dc.date.accessioned2021-12-01T18:49:40Z
dc.date.available2021-12-01T18:49:40Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractIschemia and reperfusion of intestinal tissue (intestinal I/R) induce disruption of ileal contractility and chain responses of inflammatory. The aim of this study was to reveal whether therapeutic value of cannabinoid 2 (CB2) receptor activity in the intestinal I/R, via to the exogenous administration of CB2 agonist (AM-1241). Intestinal I/R injury were performed through 30-min ischemia and 150-min reperfusion of mesenteric artery in Wistar rats. The pre-administered doses of 0.1, 1, and 5 mg/kg of CB2 agonist were studied to inhibit inflammation of intestinal I/R injury including ileum smooth muscle contractility, polymorphonuclear cell migration, oxidant/antioxidant defense system, and provocative cytokines. Pre-administration with CB2 receptor agonist ensured to consider improving the disrupted contractile responses in ileum smooth muscle along with decreased the formation of MDA that production of lipid peroxidation, reversed the depleted glutathione, inhibited the expression of TNF-alpha and of IL-1 beta in the intestinal I/R of rats. Taken together results of this research, the agonistic activity of CB2 receptor for healing of intestinal I/R injury is ensuring associated with anti-inflammatory mechanisms such as the inhibiting of migration of inflammatory polymorphonuclear cells that origin of acute and initial responses of inflammation, the inhibiting of production of provocative and pro-inflammatory cytokines like TNF-alpha and IL-1 beta, the rebalancing of oxidant/antioxidant redox system disrupted in injury of reperfusion period and the supporting of physiologic defensive systems in endothelial and inducible inflammatory cells.en_US
dc.description.sponsorshipDuzce UniversityDuzce University [2012.04. HD. 057]en_US
dc.description.sponsorshipThis study was extracted from the thesis titled 'The investigation of the effects of cannabinoids on the ileum smooth muscle function disorders in the injury of rat small bowel ischemia/reperfusion'. The study was supported as financial with project number 2012.04. HD. 057 by Duzce University.en_US
dc.identifier.doi10.1111/fcp.12502
dc.identifier.endpage90en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85071329149en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org/10.1111/fcp.12502
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10760
dc.identifier.volume34en_US
dc.identifier.wosWOS:000484102600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcannabinoid 2 receptor agonisten_US
dc.subjectIL-1 betaen_US
dc.subjectileum contractilityen_US
dc.subjectinflammationen_US
dc.subjectintestinal ischemia and reperfusionen_US
dc.subjectoxidative injuryen_US
dc.subjectTNF-alphaen_US
dc.subjectMultiple Organ Failureen_US
dc.subjectEndocannabinoid Systemen_US
dc.subjectCb2 Receptoren_US
dc.subjectNitric-Oxideen_US
dc.subjectRat Modelen_US
dc.subjectSelective Activationen_US
dc.subjectL-Arginineen_US
dc.subjectIn-Vitroen_US
dc.subjectIschemia/Reperfusionen_US
dc.subjectProtectsen_US
dc.titleThe curative effect of cannabinoid 2 receptor agonist on functional failure and disruptive inflammation caused by intestinal ischemia and reperfusionen_US
dc.typeArticleen_US

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