Antioxidant and Apoptotic Effect of Edaravone on Cisplatin-Induced Brain Injury in Rats

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dc.authorscopusid55820911000en_US
dc.authorscopusid56495523600en_US
dc.contributor.authorKara, O.
dc.contributor.authorKilitci, A.
dc.date.accessioned2024-08-23T16:07:41Z
dc.date.available2024-08-23T16:07:41Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractPurpose: This study aims to investigate the effect of edaravone in preventing cisplatin-induced brain damage. Methods: Forty female Wistar albino rats were included in the study. 4 groups were created. In group 1 (control group) (n=10), neither any drugs were given nor anything was performed. Group 2 (cisplatin group) (n=10), single dose 7.5 mg/kg cisplatin was given. In group 3 (edaravone group) (n=10), single dose 1 mg/kg edaravone was administered. Group 4 (cisplatin+ edaravone group) (n=10), single dose 7.5 mg/kg cisplatin and 1 mg/kg edaravone were given. Brain tissue was removed in all rats after 3 days. Blood samples taken from heart tissue were examined for malondialdehyde (MDA) and nitric oxide (NO) levels. Brain tissue was evaluated for damage with p53, GFAP and Ki 67. Results: Edaravone reduced cisplatin-induced brain damage. MDA and NO levels in the cisplatin group were significantly higher than the other groups (p< 0.05). Likewise, tissue damage in the cisplatin group was significantly higher than in the other groups (p< 0.05). The immunohistochemical staining which was done by using p53, GFAP and Ki 67 was shown that tissue damage was higher in cisplatin group than cisplatin+ edaravone group and this difference was found to be statistically significant (p< 0.05). Conclusion: The findings of our study suggest that edaravone therapy may be effective in the prevention and treatment of cisplatin-induced brain injury. © 2024, Neurological Society R.O.C (Taiwan). All rights reserved.en_US
dc.identifier.endpage13en_US
dc.identifier.issn1028-768X
dc.identifier.issue1en_US
dc.identifier.pmid37848239en_US
dc.identifier.scopus2-s2.0-85174748861en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14786
dc.identifier.volume33en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNeurological Society R.O.C (Taiwan)en_US
dc.relation.ispartofActa Neurologica Taiwanicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectbrainen_US
dc.subjectCisplatinen_US
dc.subjectedaravoneen_US
dc.subjectraten_US
dc.subjectAnimalsen_US
dc.subjectAntioxidantsen_US
dc.subjectAntipyrineen_US
dc.subjectBrain Injuriesen_US
dc.subjectCisplatinen_US
dc.subjectEdaravoneen_US
dc.subjectFemaleen_US
dc.subjectFree Radical Scavengersen_US
dc.subjectKi-67 Antigenen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectTumor Suppressor Protein p53en_US
dc.subjectcisplatinen_US
dc.subjectedaravoneen_US
dc.subjectglial fibrillary acidic proteinen_US
dc.subjectKi 67 antigenen_US
dc.subjectmalonaldehydeen_US
dc.subjectnitric oxideen_US
dc.subjectprotein p53en_US
dc.subjectantioxidanten_US
dc.subjectcisplatinen_US
dc.subjectedaravoneen_US
dc.subjectKi 67 antigenen_US
dc.subjectphenazoneen_US
dc.subjectprotein p53en_US
dc.subjectscavengeren_US
dc.subjectanimal experimenten_US
dc.subjectantioxidant activityen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectbiochemistryen_US
dc.subjectblood samplingen_US
dc.subjectbrain injuryen_US
dc.subjectbrain tissueen_US
dc.subjectconnective tissueen_US
dc.subjectcontrolled studyen_US
dc.subjectedemaen_US
dc.subjectenzyme linked immunosorbent assayen_US
dc.subjectfemaleen_US
dc.subjectgene expression levelen_US
dc.subjectheart tissueen_US
dc.subjectimmunohistochemistryen_US
dc.subjectinflammationen_US
dc.subjectlight microscopyen_US
dc.subjectnerve cell degenerationen_US
dc.subjectnonhumanen_US
dc.subjectphotographyen_US
dc.subjectraten_US
dc.subjectsingle drug doseen_US
dc.subjecttissue injuryen_US
dc.subjectanimalen_US
dc.subjectWistar raten_US
dc.titleAntioxidant and Apoptotic Effect of Edaravone on Cisplatin-Induced Brain Injury in Ratsen_US
dc.typeArticleen_US

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