Antioxidant and Apoptotic Effect of Edaravone on Cisplatin-Induced Brain Injury in Rats
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Neurological Society R.O.C (Taiwan)
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: This study aims to investigate the effect of edaravone in preventing cisplatin-induced brain damage. Methods: Forty female Wistar albino rats were included in the study. 4 groups were created. In group 1 (control group) (n=10), neither any drugs were given nor anything was performed. Group 2 (cisplatin group) (n=10), single dose 7.5 mg/kg cisplatin was given. In group 3 (edaravone group) (n=10), single dose 1 mg/kg edaravone was administered. Group 4 (cisplatin+ edaravone group) (n=10), single dose 7.5 mg/kg cisplatin and 1 mg/kg edaravone were given. Brain tissue was removed in all rats after 3 days. Blood samples taken from heart tissue were examined for malondialdehyde (MDA) and nitric oxide (NO) levels. Brain tissue was evaluated for damage with p53, GFAP and Ki 67. Results: Edaravone reduced cisplatin-induced brain damage. MDA and NO levels in the cisplatin group were significantly higher than the other groups (p< 0.05). Likewise, tissue damage in the cisplatin group was significantly higher than in the other groups (p< 0.05). The immunohistochemical staining which was done by using p53, GFAP and Ki 67 was shown that tissue damage was higher in cisplatin group than cisplatin+ edaravone group and this difference was found to be statistically significant (p< 0.05). Conclusion: The findings of our study suggest that edaravone therapy may be effective in the prevention and treatment of cisplatin-induced brain injury. © 2024, Neurological Society R.O.C (Taiwan). All rights reserved.
Açıklama
Anahtar Kelimeler
apoptosis, brain, Cisplatin, edaravone, rat, Animals, Antioxidants, Antipyrine, Brain Injuries, Cisplatin, Edaravone, Female, Free Radical Scavengers, Ki-67 Antigen, Rats, Rats, Wistar, Tumor Suppressor Protein p53, cisplatin, edaravone, glial fibrillary acidic protein, Ki 67 antigen, malonaldehyde, nitric oxide, protein p53, antioxidant, cisplatin, edaravone, Ki 67 antigen, phenazone, protein p53, scavenger, animal experiment, antioxidant activity, apoptosis, Article, biochemistry, blood sampling, brain injury, brain tissue, connective tissue, controlled study, edema, enzyme linked immunosorbent assay, female, gene expression level, heart tissue, immunohistochemistry, inflammation, light microscopy, nerve cell degeneration, nonhuman, photography, rat, single drug dose, tissue injury, animal, Wistar rat
Kaynak
Acta Neurologica Taiwanica
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
33
Sayı
1
