Discriminating Performance of Early Uterine and Cervical Artery Pulsatility and Resistivity In Pre-Invasive Cervical Lesions

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dc.contributor.authorDoğan, Ozan
dc.contributor.authorPulatoğlu, Çiğdem
dc.contributor.authorBaşbuğ, Alper
dc.contributor.authorKaya, Aşkı Ellibeş
dc.contributor.authorYassa, Murat
dc.date.accessioned2020-05-01T09:11:26Z
dc.date.available2020-05-01T09:11:26Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionyassa, murat/0000-0001-8661-1192; dogan, ozan/0000-0002-0016-8749en_US
dc.descriptionWOS: 000454997800010en_US
dc.description.abstractObjectives: The aim of the present study was to investigate the diagnostic effectiveness of uterine and cervical vascularity alone or in combination with human papillomavirus (HPV) DNA testing and with cytology. Methods: Data were prospectively collected from 129 patients in an outpatient clinic of a secondary setting. Routine liquid-based cervical cytology and HPV-DNA testing were obtained. An abnormal result of any of these high-risk types was viewed as positive. Pulsatility (PI) and resistance (RI) indices of uterine (UA) and cervical (CA) arteries were assessed by Doppler sonography. Pathological diagnosis was considered as the gold standard for assessment. Diagnostic efficiency of alone and joint screening of the three indices for discriminating cervical intraepithelial neoplasia (CIN-I) or above from below was assessed. Results: UA-RI and CA-RI were significantly lower in the HPV (+) group than in the controls (p=0.02 and p=0.03, respectively). In subsequent sub-analysis among patients with positive HPV-DNA, UA-PI was significantly higher in the HPV-16 (+) group than in the HPV-18 (+) group (p=0.04). High-risk HPV (Hr-HPV) testing had the highest sensitivity compared with Doppler and cytology (76.5%, 64.7%, and 58.5%, respectively). Combining CA-RI with cytology or Hr-HPV significantly reduced the sensitivity (23.5% and 29.4, respectively) but improved the specificity from 54.4% to 69.8% and 40.9% to 70.7%, respectively. Combining UA-PI with Hr-HPV slightly increased the positive predictivity when compared with testing Hr-HPV alone (36.1% vs. 33.3%). Conclusion: The potential of the Doppler indices of UA and CA was doubtful in discriminating CIN-I or above lesions in the early period. In addition, RI of UA and CA differed with regard to the presence of HPV infection, whereas CA-RI differed in high-risk HPV cases.en_US
dc.identifier.doi10.14744/SEMB.2018.07769en_US
dc.identifier.endpage211en_US
dc.identifier.issn1302-7123
dc.identifier.issn1308-5123
dc.identifier.issue3en_US
dc.identifier.startpage206en_US
dc.identifier.urihttps://doi.org/10.14744/SEMB.2018.07769
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5592
dc.identifier.volume52en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherYerkure Tanitim Yayincilik Hizmetleri Asen_US
dc.relation.ispartofMedical Bulletin Of Sisli Etfal Hospitalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCervical intraepithelial neoplasiaen_US
dc.subjectcervical smearsen_US
dc.subjectdoppler ultrasonographyen_US
dc.subjecthuman papilloma virusen_US
dc.subjectuterine arteryen_US
dc.titleDiscriminating Performance of Early Uterine and Cervical Artery Pulsatility and Resistivity In Pre-Invasive Cervical Lesionsen_US
dc.typeArticleen_US

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