The Effects of Erdosteine on Tracheal Healing in Rats

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dc.contributor.authorKarapolat, Sami
dc.contributor.authorGezer, Suat
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorDumlu, Talha
dc.contributor.authorKarapolat, Banu
dc.contributor.authorÖzaydın, İsmet
dc.contributor.authorKandiş, Hayati
dc.date.accessioned2020-04-30T23:33:21Z
dc.date.available2020-04-30T23:33:21Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKandis, Hayati/0000-0001-9151-6050en_US
dc.descriptionWOS: 000290428500004en_US
dc.description.abstractBackground. Proliferating scar tissue and strictures, which are still serious problems of tracheal surgery, are caused by an inflammatory reaction with subsequent edema and granulation tissue. Tracheal stenosis leads to severe morbidity and multiple surgical operations are sometimes needed in those patients. Objectives. To assess the effect of the antioxidant and anti-inflammatory drug Erdosteine to prevent tracheal stenosis in a rat model. Material and Methods. Fourteen female adult Wistar albino rats were divided into two groups, a control group (Group A, n = 7) and an Erdosteine group (Group B, n = 7). Under general anesthesia, the tracheas were incised vertically, extending from the 3(rd) to the 5(th) cartilaginous rings and closed primarily with absorbable sutures. Group A had 0.5 cc/day 0.9% NaCl, and Group B had 10 mg/kg/day Erdosteine, both administered by gavages and maintained for 10 days. At the end of the procedure, the rats were sacrificed and their tracheas were excised from cricoid cartilage to carina. The specimens were histologically evaluated using light microscopy and scored for inflammatory cell infiltration, angiogenesis, fibroblast proliferation, collagen deposition, and epithelial regeneration. All of the results were statistically analyzed and a value of p < 0.05 was considered statistically significant. Results. There were only meaningful differences in epithelial regeneration (p = 0.001), displaying that epithelial regeneration was better in Group B. However, the differences in inflammatory cell infiltration, angiogenesis, fibroblast proliferation and collagen deposition did not reach statistical significance. Conclusions. The severity of pathological changes forming in the tissue after tracheal surgery could not be reduced with Erdosteine use. Thus, Erdosteine does not seem to be an applicable preventive treatment agent for possible postsurgical tracheal stenosis (Adv Clin Exp Med 2011, 20, 1, 31-37).en_US
dc.identifier.endpage37en_US
dc.identifier.issn1899-5276
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage31en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4951
dc.identifier.volume20en_US
dc.identifier.wosWOS:000290428500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWroclaw Medical Univen_US
dc.relation.ispartofAdvances In Clinical And Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttracheaen_US
dc.subjectthoracic surgeryen_US
dc.subjectinflammationen_US
dc.subjectwound healingen_US
dc.subjecttracheal stenosisen_US
dc.subjectagentsen_US
dc.subjectanti-inflammatoryen_US
dc.titleThe Effects of Erdosteine on Tracheal Healing in Ratsen_US
dc.typeArticleen_US

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