Mean Platelet Volume (MPV) in Obstructive Sleep Apnea (OSA) and Effect of Continuous Positive Airway Pressure (CPAP) Treatment on MPV in OSA

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dc.authoridOZMEN SUNER, KEZBAN/0000-0002-9822-4031en_US
dc.contributor.authorCakiroglu, Emine Banu
dc.contributor.authorAnnakkaya, Ali Nihat
dc.contributor.authorSuner, Kezban Ozmen
dc.contributor.authorErbay, Umran Toru
dc.date.accessioned2024-08-23T16:03:50Z
dc.date.available2024-08-23T16:03:50Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: In this study, our objective was to evaluate mean platelet volume (MPV), an indirect marker of platelet activation, in patients with obstructive sleep apnea (OSA), and assess the effect of OSA treatment with continuous positive airway pressure (CPAP) on MPV. Materials and Methods: In this study, records of consecutive patients who underwent polysomnographic evaluation for OSA symptoms in the Sleep Disorders Laboratory during a one-year period were reviewed retrospectively. Patients who had both complete blood count and MPV measurements were included in the study. Results: A total of 158 patients, including 51 females (32.3%) and 107 males (67.7%), were included in the study. The mean age of the patients was 51 +/- 13 (min -18, max -82) years. OSA was detected in 74.1% (117/158) of the patients. It was determined that as the severity of OSA increased, hemoglobin and hematocrit values increased significantly. There was no significant difference in platelet count according to the presence and severity of OSA. The MPV was significantly lower in severe OSA cases compared to those without OSA and mild OSA cases. A negative correlation was observed between MPV and the apnea-hypopnea index, desaturation index, and the amount of oxygen saturation below 90% during sleep. There was no significant difference in median erythrocyte and thrombocyte counts, hematocrit percentage and hemoglobin values before and after treatment in OSA patients who used CPAP therapy. However, a significant decrease in MPV was observed after OSA treatment compared to pre-treatment. (p=0.021). Conclusions: The results of the study do not support an increase in MPV and hence platelet activation in severe OSA patients compared with those without OSA. However, the results suggest that one month of CPAP treatment reduces MPV and thus platelet activation in severe OSA patients. Further controlled, prospective studies including treatment outcomes are needed on this subject.en_US
dc.identifier.doi10.18521/ktd.1350048
dc.identifier.endpage41en_US
dc.identifier.issn1309-3878
dc.identifier.issue1en_US
dc.identifier.startpage32en_US
dc.identifier.trdizinid1229930en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.1350048
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1229930
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13929
dc.identifier.volume16en_US
dc.identifier.wosWOS:001187350400002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tıp Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSleep Apneaen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectObstructive Sleep Apneaen_US
dc.subjectPlateletsen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectActivationen_US
dc.subjectDiseaseen_US
dc.subjectEdtaen_US
dc.subjectAnticoagulantsen_US
dc.subjectAssociationen_US
dc.subjectSeverityen_US
dc.subjectIndexesen_US
dc.subjectCitrateen_US
dc.subjectRisken_US
dc.titleMean Platelet Volume (MPV) in Obstructive Sleep Apnea (OSA) and Effect of Continuous Positive Airway Pressure (CPAP) Treatment on MPV in OSAen_US
dc.typeArticleen_US

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