Heightened Serum Mitochondrial Biomarkers; FGF21 and NOS in Pediatric Anemia and a Negative Correlation between GDF15 and Serum Ferritin

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dc.authorscopusid57215970751en_US
dc.authorscopusid56078893600en_US
dc.authorscopusid59252075200en_US
dc.authorscopusid59252719200en_US
dc.authorscopusid57208314562en_US
dc.authorscopusid56815156200en_US
dc.authorscopusid6602733795en_US
dc.contributor.authorCakmak, Hatice Mine
dc.contributor.authorAlpay, Merve
dc.contributor.authorMahdizadeh, Cansu
dc.contributor.authorOzalp, Seray Cevikel
dc.contributor.authorTuray, Sevim
dc.contributor.authorOzde, Sukriye
dc.contributor.authorKocabay, Kenan
dc.date.accessioned2024-08-23T16:03:36Z
dc.date.available2024-08-23T16:03:36Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: Mitochondrial dysfunction is closely linked to chronic disorders. This study aims to explore the correlation between pediatric anemia and mitochondrial markers, specifically fibroblast growth factor 21 (FGF21), growth/differentiation factor 15 (GDF-15), and nitric oxide synthase (eNOS). Method: This study included 66 children, with 34 diagnosed with anemia and 32 in the healthy control group. Statistically significant biomarkers were determined through cutoff levels. Results: Among the participants, 34 children were classified as anemic, while 32 were categorized as healthy. The study revealed that FGF21 levels >= 0.745 pg/mL and eNOS levels >= 1.265 mu g/mL predicted anemia. Hemoglobin levels exhibited a negative correlation with FGF21 (r = -0.381; p = 0.002) and eNOS levels (r = -0.462; p < 0.001). Furthermore, a significant negative correlation was observed between GDF-15 and ferritin (r = -0.311; p = 0.019), while eNOS levels correlated positively with folate (r = 0.313; p = 0.019). Conclusions: Anemia induced elevated mitochondrial biomarkers; FGF21 and eNOS levels. The findings suggest that the long-term ramifications of anemia in childhood may be associated with mitochondrial dysfunction.en_US
dc.identifier.doi10.3390/jcm13154403
dc.identifier.issn2077-0383
dc.identifier.issue15en_US
dc.identifier.pmid39124668en_US
dc.identifier.scopus2-s2.0-85200797279en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/jcm13154403
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13815
dc.identifier.volume13en_US
dc.identifier.wosWOS:001287849700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofJournal of Clinical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNOSen_US
dc.subjectGDF15en_US
dc.subjectFGF21en_US
dc.subjectanemiaen_US
dc.subjectchilden_US
dc.subjectDysfunctionen_US
dc.subjectDiseaseen_US
dc.titleHeightened Serum Mitochondrial Biomarkers; FGF21 and NOS in Pediatric Anemia and a Negative Correlation between GDF15 and Serum Ferritinen_US
dc.typeArticleen_US

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