The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats

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dc.contributor.authorYıldırım, Mehmet
dc.contributor.authorMarangoz, Abdullah H.
dc.contributor.authorAyyıldız, Mustafa
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorMarangoz, Cafer
dc.date.accessioned2020-04-30T23:33:53Z
dc.date.available2020-04-30T23:33:53Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAYYILDIZ, Mustafa/0000-0002-6594-3080; Ankarali, Seyit/0000-0003-3752-0846; Yildirim, Mehmet/0000-0003-1798-5478en_US
dc.descriptionWOS: 000293206400003en_US
dc.descriptionPubMed: 21731075en_US
dc.description.abstractIn this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 mu g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 mu g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 mu g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 mu g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine.en_US
dc.description.sponsorshipCommittee for Scientific Research of Ondokuz Mayis UniversityOndokuz Mayis University [T235, T389]en_US
dc.description.sponsorshipThe authors would like to thank Prof Dr Yuksel Bek for the statistical analysis and Dr Leslie Scarth for help in polishing the English. This study was supported by the Committee for Scientific Research of Ondokuz Mayis University (Grant no: T235 and T389).en_US
dc.identifier.endpage219en_US
dc.identifier.issn0065-1400
dc.identifier.issn1689-0035
dc.identifier.issue2en_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5063
dc.identifier.volume71en_US
dc.identifier.wosWOS:000293206400003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNencki Inst Experimental Biologyen_US
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadenosineen_US
dc.subjectECoGen_US
dc.subjectepileptiform activityen_US
dc.subjectnitric oxideen_US
dc.subjectraten_US
dc.titleThe interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in ratsen_US
dc.typeArticleen_US

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