Interleukin-6 Levels in Tension Headache Patients

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dc.contributor.authorKoçer, Abdulkadir
dc.contributor.authorKoçer, Emel
dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorDomaç, Füsun M.
dc.contributor.authorYüksel, Hatice
dc.date.accessioned2020-04-30T23:18:32Z
dc.date.available2020-04-30T23:18:32Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionKocer, Abdulkadir/0000-0003-2866-555Xen_US
dc.descriptionWOS: 000281818200006en_US
dc.descriptionPubMed: 20664340en_US
dc.description.abstractObjective: Cytokines are pain mediators in neurovascular inflammation. This study examined interleukin 6 (IL-6) levels in the serum of tension-type headache (TTH) patients, to determine if inflammation plays a role in the pathogenesis of this condition. Methods: Serum IL-6 levels were studied in 42 patients and 37 healthy controls from the same region. Of the patients, 20 (47.6%) experiencing TTH less than 15 days per month were placed in episodic tension-type headache (ETTH) group, and 22 (52.3%) with TTH more than 15 days per month were placed in chronic tension-type headache (CTTH) group. Results: The IL-6 level was significantly higher in the patients than in the controls. The IL-6 level of CTTH patients was higher than the controls (P < 0.01). The IL-6 level was similar between ETTH and CTTH patients. Correlation analysis revealed a positive relationship only between age and IL-6 level in the patients. Conclusions: CTTH and ETTH patients had an elevated serum IL-6 level compared with controls. Therefore, we believe that IL-6 may be involved in pain induction or inflammatory mechanisms in TTH. Furthermore studies of the possible connection between chronicity of headaches and cytokine levels are needed.en_US
dc.identifier.endpage693en_US
dc.identifier.issn0749-8047
dc.identifier.issn1536-5409
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage690en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3391
dc.identifier.volume26en_US
dc.identifier.wosWOS:000281818200006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofClinical Journal Of Painen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttension type headacheen_US
dc.subjectinterleukinsen_US
dc.subjectpainen_US
dc.subjectinflammationen_US
dc.titleInterleukin-6 Levels in Tension Headache Patientsen_US
dc.typeArticleen_US

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