Healing Effects of Single-Dose Triptolide in Rats with Severe Acute Pancreatitis

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dc.contributor.authorDulkadiroğlu, Erkan
dc.contributor.authorYıldız, Ahmet
dc.contributor.authorKaraca, Gökhan
dc.contributor.authorŞahin, Yaşar
dc.contributor.authorÖzden, Hüseyin
dc.contributor.authorKilitci, Asuman
dc.contributor.authorUmudum, Haldun
dc.date.accessioned2023-04-10T20:19:31Z
dc.date.available2023-04-10T20:19:31Z
dc.date.issued2020
dc.departmentRektörlük, Rektörlüğe Bağlı Birimler, Düzce Üniversitesi Dergilerien_US
dc.description.abstractAim: Severe acute pancreatitis (SAP) carries high morbidity and mortality risk. If theproinflammatory response phase of SAP cannot be controlled, it may result in multiorganfailure (MOF). Nuclear factor-kappa B (NF-?B) activation plays an important role in thedevelopment of MOF. In this study, it was aimed to investigate the healing effects of triptolide,an anti-inflammatory and immunosuppressive agent in rats with SAP.Material and Methods: A total of 20 Wistar-Albino rats were divided into two groups as theSAP and triptolide treatment (TT) groups. SAP was induced by intraperitoneal injection ofcerulean (50 mg/kg) in both groups. TT group was administered a single dose (0.2 mg/kg)triptolide 24 hour after the induction of SAP. Serum ALT, AST, GGT, Lipase, Glucose, ALPand amylase levels and pancreatic tissue samples were examined.Results: Serum glucose and amylase levels were found to be significantly lower in the TTgroup (p=0.011 and p=0.035, respectively). There was no significant difference between thegroups in terms of other biochemical parameters. Pancreatic edema, acinar cell degeneration,fat necrosis, intrapancreatic&perivascular inflammation, inflammation in the peripancreatic fattissue were common histopathological findings in both groups. There was no significantdifference between the groups in terms of histopathologic changes.Conclusion: Cerulein-induced pancreatitis is a successful method for experimental SAP. Thehealing effects of single-dose triptolide treatment are not evident in the early phase of SAP.The therapeutic effects of triptolide on inflammatory and oxidative stress were not significantlyapproved by histopathological and biochemical parameters by the pancreatic tissue.en_US
dc.identifier.doi10.18678/dtfd.728067
dc.identifier.endpage108en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.startpage105en_US
dc.identifier.trdizinid385799en_US
dc.identifier.urihttp://doi.org/10.18678/dtfd.728067
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/385799
dc.identifier.urihttps://hdl.handle.net/20.500.12684/11392
dc.identifier.volume22en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleHealing Effects of Single-Dose Triptolide in Rats with Severe Acute Pancreatitisen_US
dc.typeArticleen_US

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