Healing Effects of Single-Dose Triptolide in Rats with Severe Acute Pancreatitis
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Tarih
2020
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info:eu-repo/semantics/openAccess
Özet
Aim: Severe acute pancreatitis (SAP) carries high morbidity and mortality risk. If theproinflammatory response phase of SAP cannot be controlled, it may result in multiorganfailure (MOF). Nuclear factor-kappa B (NF-?B) activation plays an important role in thedevelopment of MOF. In this study, it was aimed to investigate the healing effects of triptolide,an anti-inflammatory and immunosuppressive agent in rats with SAP.Material and Methods: A total of 20 Wistar-Albino rats were divided into two groups as theSAP and triptolide treatment (TT) groups. SAP was induced by intraperitoneal injection ofcerulean (50 mg/kg) in both groups. TT group was administered a single dose (0.2 mg/kg)triptolide 24 hour after the induction of SAP. Serum ALT, AST, GGT, Lipase, Glucose, ALPand amylase levels and pancreatic tissue samples were examined.Results: Serum glucose and amylase levels were found to be significantly lower in the TTgroup (p=0.011 and p=0.035, respectively). There was no significant difference between thegroups in terms of other biochemical parameters. Pancreatic edema, acinar cell degeneration,fat necrosis, intrapancreatic&perivascular inflammation, inflammation in the peripancreatic fattissue were common histopathological findings in both groups. There was no significantdifference between the groups in terms of histopathologic changes.Conclusion: Cerulein-induced pancreatitis is a successful method for experimental SAP. Thehealing effects of single-dose triptolide treatment are not evident in the early phase of SAP.The therapeutic effects of triptolide on inflammatory and oxidative stress were not significantlyapproved by histopathological and biochemical parameters by the pancreatic tissue.
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Düzce Tıp Fakültesi Dergisi
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Cilt
22
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2
