The effects of chronic resveratrol treatment on vascular responsiveness of streptozotocin-induced diabetic rats

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dc.contributor.authorSılan, Coşkun
dc.date.accessioned2020-04-30T23:33:18Z
dc.date.available2020-04-30T23:33:18Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionSilan, Coskun/0000-0002-8352-6571; silan, coskun/0000-0002-8352-6571en_US
dc.descriptionWOS: 000256182500023en_US
dc.descriptionPubMed: 18451515en_US
dc.description.abstractDeficiency in the vasorelaxant capacity is a result of an oxidative stress in diabetic animals and seems to be an etiological factor of vascular complications of diabetes. The present study was designed to examine whether resveratrol (RSV), a polyphenolic compound which is naturally present in grape and red wine, has a protective effect on diabetic aorta. Resveratrol (5 mg/kg/d, i.p.) was administered for 42 d to streptozotocin (STZ) (60 mg/kg) induced diabetic rats. Loss of weight, hyperglycemia, and elevated levels of plasma malondialdehyde (NIDA) were observed in diabetic rats. Resveratrol treatment was significantly effective for these metabolic and biochemical abnormalities. The contractile responses of the aorta were recorded. Compared with control subjects, the aorta showed significantly enhanced contractile responses to noradrenaline (NA), but not to potassium chloride (KCI), in diabetic rats. Treatment of diabetic rats with resveratrol significantly reversed the increases in responsiveness and sensitivity of aorta to noradrenaline. In diabetic aorta, the relaxation response to acetylcholine (Ach) was found to be significantly decreased compared with control subjects, and resveratrol treatment reversed this; no such change was observed in the relaxation response to sodium nitroprusside (SNP). These results indicated that resveratrol significantly improved not only glucose metabolism and oxidative injury but also impaired vascular responses in streptozotocin induced diabetic rats.en_US
dc.identifier.doi10.1248/bpb.31.897en_US
dc.identifier.endpage902en_US
dc.identifier.issn0918-6158
dc.identifier.issue5en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage897en_US
dc.identifier.urihttps://doi.org/10.1248/bpb.31.897
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4941
dc.identifier.volume31en_US
dc.identifier.wosWOS:000256182500023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPharmaceutical Soc Japanen_US
dc.relation.ispartofBiological & Pharmaceutical Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdiabetesen_US
dc.subjectoxidative stressen_US
dc.subjectresveratrolen_US
dc.subjectvascular reactivityen_US
dc.titleThe effects of chronic resveratrol treatment on vascular responsiveness of streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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