Chitosan/poly(ethylene glycol)/hyaluronic acid biocompatible patches obtained by electrospraying

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dc.contributor.authorMutlu, Esra Cansever
dc.contributor.authorFicai, Anton
dc.contributor.authorFicai, Denisa
dc.contributor.authorYıldırım, Arzu Birinci
dc.contributor.authorYıldırım, Muhammet
dc.contributor.authorOktar, Faik Nüzhet
dc.contributor.authorDemir, Arzu
dc.date.accessioned2020-04-30T22:40:46Z
dc.date.available2020-04-30T22:40:46Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionFicai, Anton/0000-0002-1777-0525; /0000-0003-1956-4474en_US
dc.descriptionWOS: 000440076800002en_US
dc.descriptionPubMed: 30004390en_US
dc.description.abstractElectrospray is a promising technique to scale-up production of microparticles and nanoparticles. In this study, electrospraying was used in order to produce candidate biopatches (CPH) by using chitosan, poly (ethylene glycol) (PEG) and hyaluronic acid (HA). Four different ratios of polymer blend compositions (CPH1, CPH2, CPH3 and CPH4) were tested by dissolving in 2% acetic acid solution (Ac.A.). The HA amount in each blend was kept the same to designate the optimum surface with different chitosan/PEG ratios for electrospray process. Fourier-transform infrared (FTIR) microscopy, scanning electron microscopy (SEM), and atomic force microscopy (AFM) studies showed that obtained patches had highly adhesive surfaces with the aid of heterogeneously distributed micro- and nano-particles. Additionally, video images of FTIR microscopy and AFM images proved that all surfaces have similar heterogeneity except CPH2. The most homogenous surface was obtained by CPH3. Patches were directly subjected to antibacterial tests against ten different types of gram positive and gram negative bacteria using disc diffusion assay (Kirby-Bauer method). Extraordinarily there was no antibacterial property of patches coated with microparticles. Finally, biocompatibility studies were performed by using mouse fibroblast L929 cell lines (ATTC number CCL-1) to test cell adhesion and proliferation properties of the patches. Results of 72 h viability tests proved the electrospray of ternary blends had displayed good biocompatibility; in particular, CPH3 had the highest cell viability.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Research Funds through BAP Project [2018.03.03.1295]en_US
dc.description.sponsorshipMuhammet Yildirim, Arzu Birinci Yildirim and Esra Cansever Mutlu thank Bolu Abant Izzet Baysal University Research Funds through BAP Project 2018.03.03.1295.en_US
dc.identifier.doi10.1088/1748-605X/aad368en_US
dc.identifier.issn1748-6041
dc.identifier.issn1748-605X
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1088/1748-605X/aad368
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3055
dc.identifier.volume13en_US
dc.identifier.wosWOS:000440076800002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIop Publishing Ltden_US
dc.relation.ispartofBiomedical Materialsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchitosanen_US
dc.subjecthyaluronic aciden_US
dc.subjectnanoparticleen_US
dc.subjectbiocompatibilityen_US
dc.subjectelectrosprayen_US
dc.subjectpoly(ethylene glycol)en_US
dc.titleChitosan/poly(ethylene glycol)/hyaluronic acid biocompatible patches obtained by electrosprayingen_US
dc.typeArticleen_US

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