Hexagonal boron nitride nanoparticles trigger oxidative stress by modulating thiol/disulfide homeostasis

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dc.authoridkar, fatih/0000-0001-8356-9806
dc.authoridHacioglu, Ceyhan/0000-0002-0993-6118
dc.authorwosidSogut, Ibrahim/AAU-9306-2021
dc.contributor.authorKar, F.
dc.contributor.authorSogut, I
dc.contributor.authorHacioglu, C.
dc.contributor.authorGoncu, Y.
dc.contributor.authorSenturk, H.
dc.contributor.authorSenat, A.
dc.contributor.authorKanbak, G.
dc.date.accessioned2021-12-01T18:51:05Z
dc.date.available2021-12-01T18:51:05Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractBackground: Hexagonal boron nitride nanoparticles (hBN NPs) are encouraging nanomaterials with unique chemical properties in medicine and biomedical fields. Until now, the optimal hBN NP's dosage and biochemical mechanism that can be used for in vivo systems has not been fully revealed. The main aim of this article is to reveal characteristics, serum and tissue interactions and any acute cytotoxic effect of different dose of hBN NPs for the first time. Methods: hBN NPs at concentrations varying between 50-3200 mu g/kg was administered by intravenous injection to Wistar albino rats (n = 80) divided into seven dosage and control groups. Blood and tissue samples were taken after 24 hours. Results: Our findings suggested that higher doses hBN NPs caused oxidative stress on the serum of rats dose-dependently. However, hBN NPs did not affect thiol/disulfide homeostasis on kidney, liver, spleen, pancreas and heart tissue of rats. Furthermore, hBN NPs increased serum disulfide formation by disrupting the thiol/disulfide balance in rats. Also, LOOH and MPO levels increased at high doses, while CAT levels decreased statistically. Conclusion: The results revealed that hBN NPs induce oxidative stress in a dose-dependent manner by modulating thiol/disulfide homeostasis in rats at higher concentrationsen_US
dc.description.sponsorshipEskisehir Technical University Scientific Research Projects Commission [19ADP163]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Eskis comma ehir Technical University Scientific Research Projects Commission [Project No: 19ADP163].en_US
dc.identifier.doi10.1177/09603271211002892
dc.identifier.endpage1583en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue9en_US
dc.identifier.pmid33754873en_US
dc.identifier.scopus2-s2.0-85103183585en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1572en_US
dc.identifier.urihttps://doi.org/10.1177/09603271211002892
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10965
dc.identifier.volume40en_US
dc.identifier.wosWOS:000636510600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHexagonal boron nitrideen_US
dc.subjectthiol-disulfideen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.subjectParkinsons-Diseaseen_US
dc.subjectBoric-Aciden_US
dc.subjectToxicityen_US
dc.subjectParametersen_US
dc.subjectResponsesen_US
dc.subjectDamageen_US
dc.subjectAssayen_US
dc.subjectBodyen_US
dc.subjectCellen_US
dc.titleHexagonal boron nitride nanoparticles trigger oxidative stress by modulating thiol/disulfide homeostasisen_US
dc.typeArticleen_US

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