The effects of sildenafil and tadalafil on ischemia-reperfusion injury in rat ovarian torsion model

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dc.contributor.authorToğrul, Cihan
dc.contributor.authorDoğan, Ayşe Çitil
dc.contributor.authorBaşer, Eralp
dc.contributor.authorDoğan, Murat
dc.contributor.authorAlbayrak, Aynur
dc.contributor.authorÇağlar, Mete
dc.contributor.authorDelibaşı, Tuncay
dc.date.accessioned2020-04-30T23:33:30Z
dc.date.available2020-04-30T23:33:30Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000406892300008en_US
dc.description.abstractObjective: In cases of ovarian torsion (OT), reperfusion injury may further damage ovarian tissue. Tadalafil and sildenafil are phosphodiesterase-5 (PDE-5) inhibitors that are primarily used for treatment of erectile dysfunction and pulmonary hypertension. In this study, the authors investigated the effects of these agents in preventing ovarian ischemia-reperfusion injury in a rat OT model. Materials and Methods: A total of 48 young adult female Wistar Albino rats were randomized into six groups (n=8 in each group); group 1: control sham operated, group 2: sildenafil one mg/kg, group 3: tadalafil one mg/kg, group 4: sildenafil one mg/kg + ischemia/reperfusion, (I/R) two hours of ischemia and two hours of reperfusion and a single dose of oral one mg/kg sildenafil one hour before I/R, group 5: I/R, and group 6: tadalafil one mg/kg + YR two hours of ischemia and two hours of reperfusion and a single dose of oral one mg/kg tadalafil one hour before I/R. Histopathologic evaluation was performed and scored according to the degree of congestion, edema, and hemorrhage. Total histological score (THS), tissue protein carbonyl (PC), malondialdehyde (MDA) levels, and catalase (CAT) activity were also calculated. Results: Group 4, group 5, and group 6 had similar congestion, edema and THS (p > 0.05). Group 6 had significantly lower hemorrhage score, when compared with group 5 (p = 0.03). Mean PC, MDA levels, and CAT were similar between groups 4, 5, and 6 (p > 0.05). Conclusions: Tadalafil was associated with a decreased tissue hemorrhage score in I/R injury in rat ovarian torsion model.en_US
dc.description.sponsorshipTurkish Academy of Science (TUBA)Turkish Academy of Sciencesen_US
dc.description.sponsorshipErsin Fadillioglu and Tuncay Delibasi were partly supported financially by The Turkish Academy of Science (TUBA)en_US
dc.identifier.doi10.12891/ceog3426.2017
dc.identifier.endpage539en_US
dc.identifier.issn0390-6663
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage535en_US
dc.identifier.urihttps://doi.org/10.12891/ceog3426.2017
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4985
dc.identifier.volume44en_US
dc.identifier.wosWOS:000406892300008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectReperfusion injuryen_US
dc.subjectPhosphodiesterase inhibitorsen_US
dc.subjectOvaryen_US
dc.titleThe effects of sildenafil and tadalafil on ischemia-reperfusion injury in rat ovarian torsion modelen_US
dc.typeArticleen_US

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