Alteration of tissue expression of human beta defensin-1 and human beta defensin-2 in psoriasis vulgaris following phototherapy

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dc.contributor.authorUzunçakmak, Tuğba Kevser
dc.contributor.authorKaradağ, Ayşe Serap
dc.contributor.authorÖzkanlı, Şeyma
dc.contributor.authorAkbulak, Özge
dc.contributor.authorÖzlü, Emin
dc.contributor.authorAkdeniz, Necmettin
dc.contributor.authorOğuztüzün, Serpil
dc.date.accessioned2020-04-30T22:39:04Z
dc.date.available2020-04-30T22:39:04Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionUzuncakmak, Tugba Kevser Ustunbas/0000-0001-8057-3463en_US
dc.descriptionWOS: 000492502600001en_US
dc.descriptionPubMed: 31650859en_US
dc.description.abstractWe compared the expression profiles of antimicrobial peptides (AMPs) in psoriatic skin before and after narrow band ultraviolet B (nb-UVB) phototherapy and compared the levels to healthy controls. We studied 15 male and 12 female patients with psoriasis vulgaris, and 11 female and nine male control individuals. The patient group was treated with 24-36 sessions of nb-UVB phototherapy. Immunohistochemical staining for human beta defensin 1 (hBD-1) and human beta defensin 2 (hBD-2) expression of lesioned and control skin was performed prior to and following phototherapy. After phototherapy, the psoriatic area and severity index (PASI) decreased significantly in the treated patients compared to controls. The hBD-1 level was significantly higher in psoriasis patients than healthy controls. We found no statistically significant difference in hBD-1 and hBD 2 levels before and after phototherapy in the patient group. Although hBD-1 plays a role in psoriasis, levels of human beta defensin 1 and 2 are not affected significantly by phototherapy.en_US
dc.identifier.doi10.1080/10520295.2019.1673901en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1673901
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2590
dc.identifier.wosWOS:000492502600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantimicrobial peptidesen_US
dc.subjectbeta defensin-1en_US
dc.subjectbeta defensin-2en_US
dc.subjecthumanen_US
dc.subjectphototherapyen_US
dc.subjectpsoriasisen_US
dc.titleAlteration of tissue expression of human beta defensin-1 and human beta defensin-2 in psoriasis vulgaris following phototherapyen_US
dc.typeArticleen_US

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