Effects of Naphthoquinones from the Roots of Onosma Armeniacum Klokov on Wound Healing

Basit Öğe Kaydı
dc.authoridSubaş, Tuğba/0000-0002-0956-6567en_US
dc.authoridKupeli Akkol, Esra/0000-0002-5829-7869en_US
dc.authorscopusid23096992900en_US
dc.authorscopusid57225991558en_US
dc.authorscopusid56048133600en_US
dc.authorscopusid35099613700en_US
dc.authorscopusid56020070400en_US
dc.authorscopusid25649540400en_US
dc.authorwosidSüntar, İpek/AHE-1026-2022en_US
dc.authorwosidSubaş, Tuğba/AAL-3483-2021en_US
dc.contributor.authorKupeli Akkol, Esra
dc.contributor.authorSubas, Tugba
dc.contributor.authorOzgen, Ufuk
dc.contributor.authorSuntar, Ipek
dc.contributor.authorIlhan, Mert
dc.contributor.authorKeles, Hikmet
dc.date.accessioned2024-08-23T16:07:18Z
dc.date.available2024-08-23T16:07:18Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractIn Turkish folk medicine, the roots of Onosma armeniacum Klokov are used to heal wounds, burns, hemorrhoids, hoarseness, dyspnea, stomach ulcers, and abdominal aches. The objective was to evaluate the plant's ethnopharmacological applications using in vivo pharmacological experimental models. In vivo linear incision and circular excision the wound models were used to assess the wound healing activity along with histopathological investigation. The active component(s) were isolated and identified after being exposed to several chromatographic separation procedures on the primary extract. The n-hexane-dichloromethane mixture extract was subjected to chromatographic separation after the wound-healing activity was confirmed. Deoxyshikonin (1), beta,beta-dimethylacrylshikonin (2), alpha-methyl-n-butylshikonin (3), isovalerylshikonin (4), acetylshikonin (5), beta-hydroxyisovalerylshikonin (6), and 5,8-O-dimethylacetylshikonin (7) were identified as the structures of the isolated compounds. The efficacy of O. armeniacum to heal wounds was investigated in this study. Shikonin derivatives were identified as the primary active components of the roots by bioassay-guided fractionation and isolation procedures.en_US
dc.identifier.doi10.1002/cbdv.202301946
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue4en_US
dc.identifier.pmid38433095en_US
dc.identifier.scopus2-s2.0-85187917610en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202301946
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14584
dc.identifier.volume21en_US
dc.identifier.wosWOS:001186441100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOnosma armeniacumen_US
dc.subjectBoraginaceaeen_US
dc.subjectExcision woundsen_US
dc.subjectIncision woundsen_US
dc.subjectWound healingen_US
dc.titleEffects of Naphthoquinones from the Roots of Onosma Armeniacum Klokov on Wound Healingen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu