Effect of high-fat diet on the various morphological parameters of the ovary

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dc.authoridTOPAL, Fatma/0000-0003-3491-4970
dc.authoridAYDAR, Yuksel/0000-0002-0285-9914
dc.authoridguler, sabire/0000-0002-7367-6859
dc.authorwosidTOPAL, Fatma/V-8071-2019
dc.contributor.authorHilal, Goren
dc.contributor.authorFatma, Topal
dc.contributor.authorFerruh, Yucel
dc.contributor.authorSabire, Guler
dc.contributor.authorYuksel, Aydar
dc.date.accessioned2021-12-01T18:50:07Z
dc.date.available2021-12-01T18:50:07Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractIncreased food consumption rich in fat and carbohydrate and sedentary lifestyle have seriously increased the rates of obesity and obesity-associated diseases in developed countries. Female mice with diet-induced obesity exhibit infertility and thus can serve as a model for human polycystic ovary syndrome. The aim of the present study was to examine how ovary is affected by diet-induced obesity. The effects of high-fat diet (HFD) on ovary morphology in mice fed with HFD were investigated using unbiased stereological methods. The ovary of mice fed with HFD (n=8, C1090-60, Altromine) for 9 weeks, were compared with that of mice fed with standard chow diet (n=8, C1090-10, Altromine). Stereological parameters were obtained in diestrus cycle. The samples were processed through routine and standard paraffin embedding and were serially sectioned in 5-mu m thickness then, every 10th section was saved, stained with Crossman's triple stain for counting and measuring. In all sampled sections mean follicle numbers, diameters, total ovarian volume cortex to medulla ratio (Vv), ovum to cell ratio in secondary follicle were examined in all sampled sections. The present results showed that weight of ovarian and amount of intraperitoneal adipose tissue and the body weight markedly increased in obese mice when compared with control groups. Moreover, follicle numbers (except primordial follicles) and diameters were significantly increased in obese mice. Cortex to medulla ratio (Vv) and ovum to cell ratio in secondary follicle were also considerably different between experimental and the control groups. The present findings indicate that obesity adversely affects overall ovarian morphology.en_US
dc.description.sponsorshipEskisehir Osmangazi University Research Projects Center [2014-586]en_US
dc.description.sponsorshipThe present study was also financially supported by Eskisehir Osmangazi University Research Projects Center with the project code 2014-586.en_US
dc.identifier.doi10.5115/acb.19.082
dc.identifier.endpage67en_US
dc.identifier.issn2093-3665
dc.identifier.issn2093-3673
dc.identifier.issue1en_US
dc.identifier.pmid32274250en_US
dc.identifier.scopus2-s2.0-85083194261en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage58en_US
dc.identifier.urihttps://doi.org/10.5115/acb.19.082
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10828
dc.identifier.volume53en_US
dc.identifier.wosWOS:000523594600010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMedrangen_US
dc.relation.ispartofAnatomy & Cell Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh-fat dieten_US
dc.subjectMorphologyen_US
dc.subjectObesityen_US
dc.subjectOvaryen_US
dc.subjectStereologyen_US
dc.subjectIn-Vitro Fertilizationen_US
dc.subjectInduced Obesityen_US
dc.subjectOverweighten_US
dc.subjectFertilityen_US
dc.subjectGrowthen_US
dc.subjectInfertilityen_US
dc.subjectPrevalenceen_US
dc.subjectReceptoren_US
dc.subjectOutcomesen_US
dc.subjectGirlsen_US
dc.titleEffect of high-fat diet on the various morphological parameters of the ovaryen_US
dc.typeArticleen_US

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