Protective effects of Lacticaseibacillus rhamnosus on isoprenaline-induced myocardial infarction in rats

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dc.contributor.authorBeyazçicek, Ersin
dc.contributor.authorBeyazçicek, Özge
dc.date.accessioned2023-07-26T11:57:52Z
dc.date.available2023-07-26T11:57:52Z
dc.date.issued2023
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractAims Myocardial infarction (MI) is among the main public health problems in the world. This atherosclerotic cardiovascular disease (ASCVD), which seriously endangers human health, progresses to cause heart failure and myocardial fibrosis with a poor prognosis. The gut microbiota plays an important role in health and disease, including obesity and ASCVD. In this study, the protective effect of Lacticaseibacillus rhamnosus GG, known for its anti-inflammatory and antioxidant effects, on isoprenaline (ISO)-induced MI in rats was investigated. Methods and results Rats were divided into four groups of seven rats in each group as control, ISO, L. rhamnosus, and ISO + L. rhamnosus.The ISO application was made by subcutaneous injection to the rats on the last two days (days 27th and 28th) of the 28-day substance administration. The rats were anesthetized 24 hours after the application of ISO, and blood samples were collected after electrocardiogram (ECG) recordings. To determine myocardial damage and protective effects of L. rhamnosus, serum creatine kinase-MB, cardiac troponin-I, tumor necrosis factor-alpha, interleukin-10, and C-reactive protein (CRP) levels were examined. In addition, ECG recordings were evaluated. While L. rhamnosus had a decreasing effect on cardiac troponin-I, creatine kinase-MB, CRP, and tumor necrosis factor-alpha levels, which increased due to ISO, it had an increasing effect on interleukin-10 levels. Similarly, it decreased the ST-segment elevation caused by ISO while increasing the reduced R wave amplitude.en_US
dc.identifier.doi10.1093/jambio/lxac008
dc.identifier.issn1364-5072
dc.identifier.issn1365-2672
dc.identifier.issue1en_US
dc.identifier.pmid36626773en_US
dc.identifier.scopus2-s2.0-85147457630en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1093/jambio/lxac008
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13332
dc.identifier.volume134en_US
dc.identifier.wosWOS:000898376900001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorBeyazçiçek, Ersin
dc.institutionauthorBeyazçiçek, Özge
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Applied Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectMyocardial Infarction; Lacticaseibacillus Rhamnosus; Isoprenaline; Microbiotaen_US
dc.subjectGut Microbiota; Pretreatment; Probiotics; Injury; Mice; Combination; Prebiotics; Quercetin; Fibrosis; Enzymesen_US
dc.titleProtective effects of Lacticaseibacillus rhamnosus on isoprenaline-induced myocardial infarction in ratsen_US
dc.typeArticleen_US

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