Unmasking metabolic clues: adipsin, irisin and osteopontin as biomarkers in polycystic ovary syndrome and their impact on metabolic dynamics: a case-control study

Basit Öğe Kaydı
dc.contributor.authorDuzenli, Fatma Nur
dc.contributor.authorYurtcu, Engin
dc.contributor.authorKeyif, Betul
dc.contributor.authorBasbug, Alper
dc.date.accessioned2025-10-11T20:47:36Z
dc.date.available2025-10-11T20:47:36Z
dc.date.issued2025
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjectives: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, often associated with metabolic alterations.This study assessed serum levels of adipsin, irisin, and osteopontin in patients with PCOS and examined their correlations with metabolic parameters. Material and methods: A case-control studywas conducted involving 96 women with PCOS and 80 healthy controls. Serum levels of adipsin, irisin, and osteopontin were measured; demographic, clinical, and metabolic characteristics were evaluated. Results: Patients with PCOS were significantlyyoungerthan controls (p < 0.001).The PCOS group included a significantly greater proportion of obese individuals (p = 0.013). Patients with PCOS exhibited elevated serum adipsin (p = 0.020) and reduced osteopontin (p < 0.001) levels relative to controls; obesity and age influenced these differences. Osteopontin demonstrated superior predictive power for PCOS diagnosis [area under the curve (AUC) = 0.802] compared with adipsin (AUC = 0.602). A combination of osteopontin and adipsin yielded the highest predictive value (AUC = 0.817) among double or triple biomarker combinations. Conclusions:This study identified potential associations among adipsin, osteopontin, irisin, and PCOS. Further research is warranted to elucidate their roles and clinical implications in PCOS and its metabolic alterations. The findings highlight the impact of age and obesity on these biomarkers and their relationships with PCOS, providing insight into the syndrome's complex pathophysiology.en_US
dc.identifier.doi10.5603/gpl.102676
dc.identifier.issn0017-0011
dc.identifier.issn2543-6767
dc.identifier.pmid40070254en_US
dc.identifier.scopus2-s2.0-105013172381en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.5603/gpl.102676
dc.identifier.urihttps://hdl.handle.net/20.500.12684/21464
dc.identifier.wosWOS:001533602100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofGinekologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250911
dc.subjectpolycystic ovary syndromeen_US
dc.subjectadipsinen_US
dc.subjectosteopontinen_US
dc.subjectirisinen_US
dc.subjectadipokinesen_US
dc.titleUnmasking metabolic clues: adipsin, irisin and osteopontin as biomarkers in polycystic ovary syndrome and their impact on metabolic dynamics: a case-control studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu