Role of G(s) proteins in hypoxic constriction of sheep pulmonary artery rings

Basit Öğe Kaydı
dc.contributor.authorUzun, Özge
dc.contributor.authorDemiryürek, Abdullah T.
dc.contributor.authorKanzık, İlker
dc.date.accessioned2020-04-30T23:31:44Z
dc.date.available2020-04-30T23:31:44Z
dc.date.issued2002
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionDemiryurek, Abdullah/0000-0003-4762-4745en_US
dc.descriptionWOS: 000174426700008en_US
dc.descriptionPubMed: 11893903en_US
dc.description.abstractThe introduction of hypoxia is well known to cause contraction of pulmonary artery rings in vitro. Despite intensive studies, the cellular mechanisms of hypoxic pulmonary vasoconstriction are still not well defined. In this study, we aimed to determine the contribution of G(S) proteins in hypoxia-induced vasoconstriction in large-diameter sheep pulmonary arteries using cholera toxin (CT). Hypoxia caused further contractions in serotonin but not in NaF-precontracted pulmonary artery rings. However, hypoxic vasoconstriction due to lowering Of pO(2) from 97 to 5 mm Hg was totally abolished by preincubation with CT in serotonin-precontracted arteries. These preliminary results indicate that signal transduction mediated by G(S) proteins may be an important mechanism in the hypoxic vasoconstriction of isolated pulmonary arteries of sheep. Copyright (C) 2002 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000056174en_US
dc.identifier.endpage216en_US
dc.identifier.issn0031-7012
dc.identifier.issue4en_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.1159/000056174
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4440
dc.identifier.volume64en_US
dc.identifier.wosWOS:000174426700008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofPharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthypoxiaen_US
dc.subjectG(s) proteinsen_US
dc.subjectpulmonary artery, sheepen_US
dc.titleRole of G(s) proteins in hypoxic constriction of sheep pulmonary artery ringsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
4440.pdf
Boyut:
150.49 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu