Role of G(s) proteins in hypoxic constriction of sheep pulmonary artery rings
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Date
2002
Journal Title
Journal ISSN
Volume Title
Publisher
Karger
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
The introduction of hypoxia is well known to cause contraction of pulmonary artery rings in vitro. Despite intensive studies, the cellular mechanisms of hypoxic pulmonary vasoconstriction are still not well defined. In this study, we aimed to determine the contribution of G(S) proteins in hypoxia-induced vasoconstriction in large-diameter sheep pulmonary arteries using cholera toxin (CT). Hypoxia caused further contractions in serotonin but not in NaF-precontracted pulmonary artery rings. However, hypoxic vasoconstriction due to lowering Of pO(2) from 97 to 5 mm Hg was totally abolished by preincubation with CT in serotonin-precontracted arteries. These preliminary results indicate that signal transduction mediated by G(S) proteins may be an important mechanism in the hypoxic vasoconstriction of isolated pulmonary arteries of sheep. Copyright (C) 2002 S. Karger AG, Basel.
Description
Demiryurek, Abdullah/0000-0003-4762-4745
WOS: 000174426700008
PubMed: 11893903
WOS: 000174426700008
PubMed: 11893903
Keywords
hypoxia, G(s) proteins, pulmonary artery, sheep
Journal or Series
Pharmacology
WoS Q Value
Q2
Scopus Q Value
Volume
64
Issue
4
