Tissue expression of glutathione S transferase isoenzymes in vitiligo

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dc.authoridKAYA KOCDOGAN, Arzu/0000-0002-3689-3061
dc.contributor.authorUzuncakmak, Tugba Kevser
dc.contributor.authorOzkanli, Seyma
dc.contributor.authorKocdogan, Arzu Kaya
dc.contributor.authorOguztuzun, Serpil
dc.contributor.authorKaradag, Ayse Serap
dc.contributor.authorOzlu, Emin
dc.contributor.authorAkdeniz, Necmettin
dc.date.accessioned2021-12-01T18:50:48Z
dc.date.available2021-12-01T18:50:48Z
dc.date.issued2021
dc.department[Belirlenecek]en_US
dc.description.abstractThe association of glutathione S-transferase (GST) enzymes with vitiligo is inconclusive. To evaluate tissue expressions of GST isoenzymes in vitiligo patients and to compare these expressions with healthy controls, we used 26 active depigmented patches on the trunk of vitiligo patients and 20 healthy sex and age matched controls. Punch biopsies were taken from the lesioned or normal skin. Tissue expression of GST isoenzymes were analyzed immunohistochemically. Tissue expression of GSTT1, GSTA1 and GSTP1 was significantly higher in the patient group than controls. Tissue expression of GSTM1 was not significantly different between the two groups. The increased tissue expression of GSTT1, GSTA1 and GSTP1 may represent a response to excess free radical formation in vitiligo and may support the role of oxidative stress in the pathogenesis of vitiligo.en_US
dc.identifier.doi10.1080/10520295.2021.1977998
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.pmid34547977en_US
dc.identifier.scopus2-s2.0-85115232607en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1977998
dc.identifier.urihttps://hdl.handle.net/20.500.12684/10927
dc.identifier.wosWOS:000698255600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectdermatologyen_US
dc.subjectglutathione S transferaseen_US
dc.subjecthumanen_US
dc.subjectoxidative stressen_US
dc.subjectpathologyen_US
dc.subjectvitiligoen_US
dc.subjectProtein Expressionen_US
dc.subjectGene Polymorphismsen_US
dc.subjectOxidative Stressen_US
dc.subjectSusceptibilityen_US
dc.subjectAssociationen_US
dc.subjectMelanomaen_US
dc.subjectGstm1en_US
dc.subjectGstt1en_US
dc.subjectT1en_US
dc.subjectM1en_US
dc.titleTissue expression of glutathione S transferase isoenzymes in vitiligoen_US
dc.typeArticleen_US

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