LoxBlock-1 or Curcumin attenuates liver, pancreas and cardiac ferroptosis, oxidative stress and injury in Ischemia/reperfusion-damaged rats by facilitating ACSL/GPx4 signaling

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dc.authoridkar, fatih/0000-0001-8356-9806en_US
dc.authoridKAR, Ezgi/0000-0003-2134-4067en_US
dc.authorscopusid57208669078en_US
dc.authorscopusid57226443555en_US
dc.authorscopusid57208671422en_US
dc.authorscopusid57214228253en_US
dc.authorscopusid25228183400en_US
dc.authorscopusid35320276300en_US
dc.authorscopusid6603920397en_US
dc.authorwosidkar, fatih/HJY-4385-2023en_US
dc.authorwosidKAR, Ezgi/AAR-1992-2020en_US
dc.contributor.authorKar, Fatih
dc.contributor.authorYildiz, Fatma
dc.contributor.authorHacioglu, Ceyhan
dc.contributor.authorKar, Ezgi
dc.contributor.authorDonmez, Dilek Burukoglu
dc.contributor.authorSenturk, Hakan
dc.contributor.authorKanbak, Gungor
dc.date.accessioned2024-08-23T16:04:32Z
dc.date.available2024-08-23T16:04:32Z
dc.date.issued2023en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractIn this study, the effects of the pretreatment of Curcumin and LoxBlock-1 on liver, pancreas, and cardiac dysfunction following Ischemia-Reperfusion-induced (IR) Acute Kidney Injury (AKI) were investigated through the mechanisms of oxidative stress and ferroptosis. Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) parameters in the tissue were analyzed to investigate the oxidative stress occurring in the liver, pancreas, and heart, and Acyl-Coa synthetase long-chain family member (ACSL4). Glutathione peroxidase 4 (GPx4) enzyme levels were also analyzed by ELISA to investigate the effect on ferroptosis. In addition, hematoxylin-eosin staining was performed for histopathological examination of the tissues. As a result of biochemical analyzes, it was observed that oxidative stress parameters increased significantly in the IR group. In addition, while the ACSL4 enzyme level increased in the IR group in all tissues, the GPx4 enzyme level decreased. In the histopathological examination, it was observed that IR caused serious damage to the heart, liver, and pancreas tissues. The present study shows that Curcumin and LoxBlock-1 have a protective effect on the liver, pancreas, and cardiac ferroptosis following the effect on AKI. In addition, Curcumin was found to be more effective than LoxBlock-1 in I/R injury with its antioxidant property.en_US
dc.identifier.doi10.1016/j.tice.2023.102114
dc.identifier.issn0040-8166
dc.identifier.pmid37210761en_US
dc.identifier.scopus2-s2.0-85159627498en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.tice.2023.102114
dc.identifier.urihttps://hdl.handle.net/20.500.12684/14254
dc.identifier.volume82en_US
dc.identifier.wosWOS:001012849800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofTissue & Cellen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAKIen_US
dc.subjectRenal IRen_US
dc.subjectCurcuminen_US
dc.subjectLoxBlock-1en_US
dc.subjectFerroptosisen_US
dc.subjectRenal Ischemiaen_US
dc.titleLoxBlock-1 or Curcumin attenuates liver, pancreas and cardiac ferroptosis, oxidative stress and injury in Ischemia/reperfusion-damaged rats by facilitating ACSL/GPx4 signalingen_US
dc.typeArticleen_US

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