Clinical and radiological findings in macroprolactinemia

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dc.contributor.authorIşık, Serhat
dc.contributor.authorBerker, Dilek
dc.contributor.authorTütüncü, Yasemin Ateş
dc.contributor.authorÖzuğuz, Ufuk
dc.contributor.authorGökay, Ferhat
dc.contributor.authorErden, Gönül
dc.contributor.authorGüler, Serdar
dc.date.accessioned2020-04-30T22:40:51Z
dc.date.available2020-04-30T22:40:51Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000303584800021en_US
dc.descriptionPubMed: 22187359en_US
dc.description.abstractHyperprolactinemia is the most common abnormality of the hypothalamic-pituitary axis. The aim of this study was to investigate the clinical and radiological features of patients with macroprolactinemia. The study population consisted of patients with elevated serum prolactin (PRL) concentrations who presented to our Endocrinology outpatient clinic. Detection of macroprolactin (macroPRL) was performed using the polyethylene glycol precipitation method. Patients in which macroPRL made up more than 60% of total PRL levels were stratified into the macroPRL group, while the remaining patients were placed in the monomeric prolactin (monoPRL) group. A total of 337 patients were enrolled with a mean age of 33.8 +/- 10.8 (16-66) years and a male/female ratio of 29/308. Eighty-eight of the patients (26.1%) had an elevated macroPRL level. The mean age in the monoPRL group was higher than in the macroPRL group (35.0 +/- 10.1 vs. 30.7 +/- 9.8, P = 0.016). The mean PRL levels (ng/ml) in the macroPRL and monoPRL groups were similar (168.0 +/- 347.0 vs. 238.8 +/- 584.9, P = 0.239). Frequency of amenorrhea, infertility, irregular menses, gynecomastia, and erectile dysfunction were also similar in both groups. More patients in the macroPRL group were asymptomatic compared to the monoPRL group (30.2 vs. 12.0%, P = 0.006). Compared to the macroPRL group, the monoPRL group had a higher frequency of galactorrhea (39.2 vs. 57.1%, P = 0.04) and abnormal magnetic resonance imaging findings (65.3 vs. 81.1%, P = 0.02). Elevated macroPRL levels should be considered a pathological biochemical variant of hyperprolactinemia that may present with any of the conventional symptoms and radiological findings generally associated with elevated PRL levels.en_US
dc.identifier.doi10.1007/s12020-011-9576-9en_US
dc.identifier.endpage333en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage327en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-011-9576-9
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3071
dc.identifier.volume41en_US
dc.identifier.wosWOS:000303584800021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProlactinen_US
dc.subjectHyperprolactinemiaen_US
dc.subjectMacroprolactinen_US
dc.subjectPituitary adenomaen_US
dc.titleClinical and radiological findings in macroprolactinemiaen_US
dc.typeArticleen_US

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