What is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality?

Basit Öğe Kaydı
dc.authoridMertoğlu, Cuma/0000-0003-3497-4092
dc.authoridILKBAHAR, FATIH/0000-0002-7964-3433
dc.authoridHUYUT, Mehmet Tahir/0000-0002-2564-991X
dc.authorwosidMertoğlu, Cuma/A-3506-2017
dc.contributor.authorHuyut, Mehmet Tahir
dc.contributor.authorHuyut, Zübeyir
dc.contributor.authorİlkbahar, Fatih
dc.contributor.authorMertoğlu, Cuma
dc.date.accessioned2023-07-26T11:54:31Z
dc.date.available2023-07-26T11:54:31Z
dc.date.issued2022
dc.departmentDÜ, Ziraat Fakültesi, Biyosistem Mühendisliği Bölümüen_US
dc.description.abstractIt remains important to investigate the changing and impact of routine blood values (RBVs) in order to predict mortality and follow an appropriate treatment in COVID-19 patients. In the study, the importance of RBVs in the mortality of patients with COVID-19 was investigated. The changes in the biochemical, hematological, and immunological parameters of patients who recovered (n = 4364) and died (n = 233) from COVID-19 over time and their relationship with the mortality of the disease were evaluated retrospectively. Odds ratios of the parameters affecting one-month mortality were calculated by running multiple-logistic-regression analysis. The cut off values and diagnostic efficiencies of the parameters that posed a risk for mortality were obtained via receiver operating curve analysis. It was determined that the C-reactive protein (CRP), D-dimer, procalcitonin, erythrocyte-sedimentation-rate (ESR), troponin values were at abnormal levels until death occurred in the patients who died. In addition, the procalcitonin levels were consistently high in patients who died. The patients who died generally had a sustained increase in their leukocyte and neutrophil levels and biochemical variables, and an ongoing decrease in lymphopenia and eosinopenia levels. Although significant changes were observed in liver function tests, cardiac troponin, hemogram values, kidney function tests and parameters related to inflammation in deceased patients, high ESR, international-normalized-ratio (INR), prothrombin-time (PT), CRP, D-dimer, ferritin and red-cell-distribution width (RDW) values, respectively, were the most effective predictive mortality risk biomarkers of COVID-19. In addition, neutrophilia, leukocytosis, thrombocytopenia, erythrocytopenia were other risk predictors of mortality. Indicators was found in this study can be successfully used to predict mortality from COVID-19.en_US
dc.identifier.doi10.1016/j.intimp.2022.108542
dc.identifier.issn1567-5769
dc.identifier.issn1878-1705
dc.identifier.pmid35063753en_US
dc.identifier.scopus2-s2.0-85123001278en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2022.108542
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12854
dc.identifier.volume105en_US
dc.identifier.wosWOS:000793200000005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorİlkbahar, Fatih
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Immunopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectCovid-19; Mortality Risk Indicators; Routine Laboratory Characteristics; Hypercoagulation; Leukocytosis; Erythrocytopeniaen_US
dc.titleWhat is the impact and efficacy of routine immunological, biochemical and hematological biomarkers as predictors of COVID-19 mortality?en_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
12854.pdf
Boyut:
5.3 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu