Tumour necrosis factor alpha, interleukin 10 and interleukin 6 gene polymorphisms of ischemic stroke patients in south Marmara region of Turkey

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dc.contributor.authorÖzkan, Adile
dc.contributor.authorSılan, Fatma
dc.contributor.authorUludağ, Ahmet
dc.contributor.authorDeğirmenci, Yıldız
dc.contributor.authorKaraman, Handan Işın Özışık
dc.date.accessioned2020-04-30T23:46:49Z
dc.date.available2020-04-30T23:46:49Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000367814200184en_US
dc.descriptionPubMed: 26722564en_US
dc.description.abstractBackground: Stroke is an important cause of adult mortality and morbidity; however its pathogenesis is still unknown. Several studies have examined to determine the role of genetic polymorphism of proinflammatory cytokines in the occurence of stroke. The objective of this study was to evaluate the relationship between three polymorphisms; including tumour necrosis alpha (TNF alpha)-238 GA, interleukin(IL-10)-1028 GA (rs1800896), IL-6-(rs1800795) and ischemic stroke in a Turkish population. Methods: Forty two stroke patients and 48 healhty controls were genotyped using PCR analysis for TNF alpha-238 G/A, IL-10-1028 GA and IL-6-rs1800795 AG polymorphisms. Results: The frequency of the CC and CG, GG genotype of IL-6 gene (rs1800795) were statiscially significiantly higher in IS patients than controls (for C/C genotype, P=0.03, OR=4.3; 95% CI: 1.13 to 16.29 and for C/G genotype, P=0.04, OR=3.6; 95% CI: 1.03 to 12.95, for G/G genotype, P=0.02, OR=0.25; 95% CI: 0.07-0.85 respectively). Conclusion: IL-6 CC genotyped was found strongly associated with ischemic stroke than other two polymorpisms TNF-alpha and IL-10 in our population.en_US
dc.identifier.endpage13504en_US
dc.identifier.issn1936-2625
dc.identifier.issue10en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage13500en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5278
dc.identifier.volume8en_US
dc.identifier.wosWOS:000367814200184en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal Of Clinical And Experimental Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStrokeen_US
dc.subjectTNF-alphaen_US
dc.subjectIL-6en_US
dc.subjectIL-10en_US
dc.subjectpolymorhismsen_US
dc.titleTumour necrosis factor alpha, interleukin 10 and interleukin 6 gene polymorphisms of ischemic stroke patients in south Marmara region of Turkeyen_US
dc.typeArticleen_US

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