Is there any relationship between decreased AgNOR protein synthesis and human hair loss?

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dc.contributor.authorEröz, Recep
dc.contributor.authorTaşdemir, Şener
dc.contributor.authorDoğan, Hasan
dc.date.accessioned2020-04-30T23:18:46Z
dc.date.available2020-04-30T23:18:46Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionDogan, Hasan/0000-0002-5232-4336en_US
dc.descriptionWOS: 000309939900002en_US
dc.descriptionPubMed: 22747173en_US
dc.description.abstractArgyrophilic nucleolar organizing region associated proteins (AgNORs) play roles in cell proliferation and a variety of diseases. We attempted to determine whether decreased NOR protein synthesis causes human hair loss. We studied 21 healthy males who suffered hair loss on the frontal/vertex portion of the head. Hair root cells from normal and hair loss sites were stained for AgNOR. One hundred nuclei per site were evaluated and the AgNOR number and NORa/TNa proportions of individual cells were determined using a computer program. The cells from normal sites had significantly higher AgNOR counts than those from hair loss sites. Also, the cells from the normal sites had significantly higher NORa/TNa than cells from the hair loss sites. In the normal sites, the cells demonstrated more NOR protein synthesis than cells in hair loss sites. Therefore, decreased NOR protein synthesis appears to be related to hair loss in humans.en_US
dc.identifier.doi10.3109/10520295.2012.698307en_US
dc.identifier.endpage498en_US
dc.identifier.issn1052-0295
dc.identifier.issue8en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage494en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2012.698307
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3519
dc.identifier.volume87en_US
dc.identifier.wosWOS:000309939900002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgNORsen_US
dc.subjecthair follicleen_US
dc.subjecthair lossen_US
dc.subjectrDNAen_US
dc.titleIs there any relationship between decreased AgNOR protein synthesis and human hair loss?en_US
dc.typeArticleen_US

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