The regulation of adipokines related to obesity and diabetes is sensitive to BDNF levels and adipose tissue location

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dc.authoridALVER, AHMET/0000-0002-9617-6689
dc.authoridabidin, ismail/0000-0003-2510-9718
dc.authorwosidALVER, AHMET/GQA-9100-2022
dc.authorwosidALVER, AHMET/AAH-4599-2021
dc.authorwosidAbidin, İsmail/AAH-6286-2021
dc.authorwosidkahraman, cemil/HRC-3465-2023
dc.authorwosidabidin, ismail/AGP-3973-2022
dc.contributor.authorAkça, İmran İnce
dc.contributor.authorBodur, Akın
dc.contributor.authorKahraman, Cemil
dc.contributor.authorAbidin, İsmail
dc.contributor.authorAydın-Abidin, Selcen
dc.contributor.authorAlver, Ahmet
dc.date.accessioned2023-07-26T11:51:08Z
dc.date.available2023-07-26T11:51:08Z
dc.date.issued2022
dc.departmentDÜ, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractPurpose The role of BDNF in adipose tissue metabolism is poorly understood. We investigated the effects of decreased levels of BDNF on the expression of major adipokines in different fat depots (e.g., subcutaneous and epididymal) of mouse groups fed three different diet protocols. Methods BDNF heterozygous (+ / -) mice were used to evaluate the effect of reduced BDNF levels. Six groups of C57BL/6 J breed wild type (WT) and BDNF (+ / -) mice were formed. These groups were fed, respectively, a control diet (CD), a high-fat diet (HFD), and a high-sucrose diet (HSD) for 4 months. Serum samples and adipose tissues were used for biochemical assays. The serum concentrations and tissue expression levels of leptin, adiponectin, and resistin were measured. Results Compared to the CD-fed WT group (control group), serum leptin and leptin expression levels were found to be higher in all experimental groups. Serum adiponectin levels were lower in the BDNF (+ / -) groups and HFD-fed WT group than in the control group. Epididymal adiponectin expression was found to be lower in the HFD-fed BDNF (+ / -) group and higher in HSD-fed groups than in the control group. Compared to the control group, adiponectin expression increased in the WT groups in subcutaneous adipose tissue. Serum resistin levels were elevated in the HFD-fed groups. Resistin expression in epididymal adipose tissue was lower in the CD-fed and HFD-fed groups than in the control group. Conclusions BDNF levels and diet differentially affect the expression of adipokines in different fat tissues in the body. BDNF may play a protective role in obesity and diabetes.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114S553]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) [Grant No. 114S553].en_US
dc.identifier.doi10.1007/s42000-022-00364-z
dc.identifier.endpage303en_US
dc.identifier.issn1109-3099
dc.identifier.issn2520-8721
dc.identifier.issue2en_US
dc.identifier.pmid35298831en_US
dc.identifier.scopus2-s2.0-85126440153en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage295en_US
dc.identifier.urihttps://doi.org/10.1007/s42000-022-00364-z
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12500
dc.identifier.volume21en_US
dc.identifier.wosWOS:000770193400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKahraman, Cemil
dc.language.isoenen_US
dc.publisherSpringer Int Publ Agen_US
dc.relation.ispartofHormones-International Journal of Endocrinology and Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectBrain-Derived Neurotrophic Factor (Bdnf); Epididymal Adipose Tissue; High-Sucrose Diet; High-Fat Diet; Subcutaneous Adipose Tissueen_US
dc.subjectNeurotrophic Factor; High-Fat; Insulin-Resistance; Endocrine Organ; Brain; Expression; Adiponectin; Miceen_US
dc.titleThe regulation of adipokines related to obesity and diabetes is sensitive to BDNF levels and adipose tissue locationen_US
dc.typeArticleen_US

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